Abstract: Objective To investigate human papilloma virus（HPV） prevalence and HPV genotypes distribution of cervical carcinoma and cervical lesions patients in Uygur and Han， and analyze their differences between two ethnic groups.
MethodsThe cervical samples of 224 Uighur and Han women（ratio of Uygur to Han was 1∶1）， who visited Xinjiang Uighur Autonomous Region Peoples Hospital during the November 2011 to May 2012， were selected. Flowthrough hybridization and gene chip technique were used to detect 21 kinds of HPV genotypes. Results Eighteen kinds of different subtypes were detected， HPV16 was the most common type in both Han and Uighur people； 18 kinds of different subtypes were detected in cervical lesions and 8 in cervical cancer. HPV subtypes tended to be focused on along with the upgrade of the cervical lesions，these subtypes which were tend to be focused on in two nations was HPV16， 18， 52， 58， 53, 39. There was no significant difference in the detection rates of these HPV genotypes between two nations（P＞0.05）. The multiple HPV infection rates were 22.13％（27／122） and 34.43％（42／122）in cervical cancer and cervical lesions patients in Uighur and Han, respectively. There were significant differences between two nations（P＜0.05）. Conclusion There are some differences between Han women and Uighur women for HPV genotypes. The multiple HPV infection rates of cervical cancer and cervical lesions in Uighur females are higher than Han females. It suggests that the rate of the multiple HPV infection might be the one of the reasons why cervical cancer incidence in Uighur significantly is higher than Han in Xinjiang.