Abstract: 【Abstract】Objective To investigate the long-term outcome and prognostic factors of nasopharyngeal carcinoma patients（NPC）treated with intensitymodulated radiotherapy（IMRT）. Methods The clinical results of 195 newly diagnosed NPC patients treated by IMRT from March 2005 to May 2010 were reviewed. According to the standard of NPC 2008 staging system，there were 9 cases of stageⅠ，24 cases of stage Ⅱ，70 cases of stage Ⅲ and 92 cases of stage Ⅳ. Survival analysis was performed with Kaplan-Meier method. Logrank test was used for evaluating the differences between groups. Multivariate prognostic factors were analyzed by Cox regression model. Results The followup rate was 995％. There were 150 patients followed-up more than 5 years. The 5-year local control rate（LCR），distant metastasis-free survival rate（DMFSR），overall survival rate（OSR）and disease-free survival rate(DESR)were 89.2％，81.9％，76.9％ and 66.2％，respectively. Multivariate analysis showed that the independent prognostic factors for 5-year OSR，DMFSR and DFSR were T stage，N stage and the combination with chemotherapy. Gender is an independent prognostic factor for 5-year DMFSR and DFSR. Conclusion NPC treated by IMRT can get good long-term survival with high quality of life. T stage，N stage and gender are important independent prognostic factors for NPC treated by IMRT. The role of combined chemotherapy for locally advanced NPC treated by IMRT needs further investigation.