关键词: 胃癌, tRNA天冬氨酸甲基转移酶1, 临床意义, 预后

Abstract: ObjectiveTo explore the expression of tRNA aspartic acid methyltransferase 1（TRDMT1） in gastric cancer tissues， and the relationship of its expression with clinical features as well as prognosis. 
MethodsFrom January 2012 to December 2013， 90 cases of gastric cancer tissues and 35 cases of corresponding normal tissues were collected in Jiangyin Hospital Affiliated to Medical College of Southeast University. Immunohistochemical SP method was used to detect the expression of TRDMT1 in the above tissues. The relationship of TRDMT1 expression with clinical features as well as overall survival（OS） was also analyzed. 
ResultsThe positive expression rate of TRDMT1 was 556％（50／90） in gastric cancer tissues， higher than 114％（4／35） of corresponding normal tissues（P＜005）. The expression of TRDMT1 in gastric cancer tissues was related with tumor size， differentiation， depth of invasion， lymph node metastasis and TNM staging（P＜005）， but not with age and gender（P＞005）. The median OS of patients with TRDMT1 positive expression was 330 months， lower than 420 months of patients with TRDMT1 negative expression（P＜005）. Multivariate Cox regression analysis showed that tumor size， differentiation， depth of invasion， lymph node metastasis， TNM staging and TRDMT1 expression were independent factors influencing OS in patients with gastric cancer（P＜005）. 
ConclusionThe elevated expression of TRDMT1 may contribute to the occurrence and development of gastric cancer and predict the prognosis of cancer gastric.

Key words: Gastric cancer, tRNA aspartic acid methyltransferase 1（TRDMT1）, Clinical significance, Prognosis