Chinese Clinical Oncology

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Autologousperipheralbloodstem celltransplantationforTcelllymphoma:aretrospectivestud

  

  • Received:2008-09-11 Revised:1900-01-01 Online:2009-02-25 Published:2009-02-25

Abstract:  【Abstract】 Objective:Toanalyzeretrospectivelytheresultsoftreatmentwithautologousperipheralbloodstemcelltransplantation(APBSCT)forTcelllymphoma(TCL).Methods:ToconductareviewofpatientswhounderwentAPBSCTforTCLfromJuly2000toApril2008.Seventeencaseswereidentifiedconsistingof10caseslymphoblasticlymphoma,4casesnasaltypeextranodalNK/T,2casesperipheralTcelllymphomas,and1caseanaplasticlargecelllymphomas.ThepatientswereclassifiedbyAnnArborstagingsystemandinternationalprognosisindex(IP1).CD34+cellpurificationofPBSCwerecarriedoutin8patients.Allthepatientsreceivedthehighdosechemotherapywithcyclophosphamide,etoposideandtotalbodyirradiation(TBI)asconditioningregimen.Results:Plateletrecovery(>20×109/L)timewas(145±402)daysandleukocyterecovery(>05×109/L)timewas(1218±263)days,whichwaswithintheexpectedranges.Aftermedianfollowupof7(194)months,theprobabilitiesof2yearoverallsur
vivalanddiseasefreesurvivalaftertransplantationwere7187% and6289%,respectively.Sixpatientswerestillindiseasefreesur
vivalaftertwoyearsofAPBSCTwithfollowupof54(2494)months.FourcasesweredeadwithinhalfayearafterAPBSCTincluding2casesofnonremissionbeforereceivingautograft,andpatientsinrelapsebeforetransplantationrelapsedagainafter3monthsandwerestillalivewithdisease.TherewasnosignificantdifferenceontheoutcomeamongthepatientsofcompleteresponsewhetherornotreceivingautologousCD34+celltransplantationbythetimeofstoppingfollowup.Conclusion:APBSCTasconsolidationtherapyinfirstcompleteorpartialresponseTCLpatientsmayofferadurablesurvivalbenefit.However,therewasminimaldurablebenefitinpatientswithrelapsedorrefractoryTCLafterautotransplantionandallogeneicHCTshouldbemoreaggressivelyexploredforthem.

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