Chinese Clinical Oncology
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Abstract: 【Abstract】 Objective:Toanalyzeretrospectivelytheresultsoftreatmentwithautologousperipheralbloodstemcelltransplantation(APBSCT)forTcelllymphoma(TCL).Methods:ToconductareviewofpatientswhounderwentAPBSCTforTCLfromJuly2000toApril2008.Seventeencaseswereidentifiedconsistingof10caseslymphoblasticlymphoma,4casesnasaltypeextranodalNK/T,2casesperipheralTcelllymphomas,and1caseanaplasticlargecelllymphomas.ThepatientswereclassifiedbyAnnArborstagingsystemandinternationalprognosisindex(IP1).CD34+cellpurificationofPBSCwerecarriedoutin8patients.Allthepatientsreceivedthehighdosechemotherapywithcyclophosphamide,etoposideandtotalbodyirradiation(TBI)asconditioningregimen.Results:Plateletrecovery(>20×109/L)timewas(145±402)daysandleukocyterecovery(>05×109/L)timewas(1218±263)days,whichwaswithintheexpectedranges.Aftermedianfollowupof7(194)months,theprobabilitiesof2yearoverallsurvivalanddiseasefreesurvivalaftertransplantationwere7187% and6289%,respectively.SixpatientswerestillindiseasefreesurvivalaftertwoyearsofAPBSCTwithfollowupof54(2494)months.FourcasesweredeadwithinhalfayearafterAPBSCTincluding2casesofnonremissionbeforereceivingautograft,andpatientsinrelapsebeforetransplantationrelapsedagainafter3monthsandwerestillalivewithdisease.TherewasnosignificantdifferenceontheoutcomeamongthepatientsofcompleteresponsewhetherornotreceivingautologousCD34+celltransplantationbythetimeofstoppingfollowup.Conclusion:APBSCTasconsolidationtherapyinfirstcompleteorpartialresponseTCLpatientsmayofferadurablesurvivalbenefit.However,therewasminimaldurablebenefitinpatientswithrelapsedorrefractoryTCLafterautotransplantionandallogeneicHCTshouldbemoreaggressivelyexploredforthem.
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URL: http://manu65.magtech.com.cn/Jwk3_lczlxzz/EN/
http://manu65.magtech.com.cn/Jwk3_lczlxzz/EN/Y2009/V14/I2/102
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