Abstract: Epidermal growth factor receptor tyrosine kinase inhibitor（EGFR-TKI） has been one of the most important treatments for advanced non-small cell lung cancer（NSCLC）. How to effectively combine EGFR-TKI with traditional chemotherapy， so as to get a better efficacy， has been given an increasing attention. The aim of this review is to introduce some combinations of EGFRTKI and chemotherapy， try to find the best combination.