Abstract: Gastric cancer is one of the most common malignancies in the world. It has continued to be a threat to human life. The progress of gastric cancer is a multifactor，multistage and multigene mutation process induced by activation of telomerase，tumor suppressor gene inactivation，oncogene activation and so on. Specific biological markers，diagnosing and predicting patients survival and treatment response，play a role in improving the quality of life for gastric cancer patients. EZH2 gene， enhancer of zeste homolog 2， is a human homolog gene of the drosophila zeste gene enhancer. A number of studies in recent years have found that the expression level of EZH2 in gastric carcinoma is significantly higher than that in normal tissue. It plays an important role in the development of gastric cancer and has a potential clinical value for improving the detection rate and treatment of gastric cancer. This paper summarizes research progress of the correlation between EZH2 and gastric cancer.