Chinese Clinical Oncology

• 综述与讲座 • Previous Articles     Next Articles

Progress on correlation between Mfn2 and RasMAPK signal pathway in breast cancer

SHAN Xijin, ZHANG Jinghua, LI Yufeng, LIU Yan.   

  1. Department of Breast Surgery, Hebei United University Affiliated Tangshan People's Hospital
  • Received:2013-09-29 Revised:2013-12-10 Online:2014-04-30 Published:2014-04-30

Abstract: Mitochondrial fusion protein 2(Mfn2)is a highly conserved transmembrane GTP enzyme, which is encoded by a newly identified tumor suppressor gene Mfn2. The antitumor effect of Mfn2 is associated with the mitogenactivated protein kinase(MAPK)signaling pathway. MAPK is a major downstream tributary of Ras signaling pathway, which plays an important role in the malignant cells, leading to the tumor invasion and metastasis. In this review, we focus on the recent discoveries on the mechanisms involved in the regulation of Mfn2 and the relationship between Mfn2 and RasMAPK signaling pathway in breast cancer.

No related articles found!
Viewed
Full text
335
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 335

  From Others local
  Times 17 318
  Rate 5% 95%

Abstract
119
Just accepted Online first Issue
0 0 119
  From Others
  Times 119
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!