Abstract: Objective To investigate the clinical efficacy and safety of vertebral radiotherapy in the treatment of spinal metastasis. Methods The data of 116 spinal metastatic tumors patients from September 2012 to February 2016 were retrospectively reviewed. All the patients were equally divided into the observation group and the control group with 58 patients in each group according to treatment. Patients in control group were treated with percutaneous vertebral angioplasty，and those in observation group were given percutaneous vertebral angioplasty combined with radiotherapy （3 Gy／f， 1／d， 5／week， 4 weeks）. Vertebral body height recovery rate and Cobb angle recovery rate were observed 1 day and 4 weeks after operation. Complications were recorded as well. Results All the patients accomplished treatment in plan. Pain relief rate in observation group was 93.1％， higher than 79.3％ of control group （P＜0.05）. The vertebral body height recovery rate and Cobb angle recovery rate in observation group were （45.36±10.33）％ and （45.96±10.45）％， higher than （42.89±10.41）％ and （41.99±8.22）％ of control group （P＜0.05）， and the two indexes were significantly higher 4 weeks after operation than those of 1 day after operation （P＜0.05）. The main complications of the two groups were bone cement leakage and discomfort of lower limbs， and the side effect of radiotherapy in observation group was mild. Conclusion Vertebral radiotherapy combined with percutaneous vertebral angioplasty in the treatment of spinal metastasis can effectively relieve pain， promote the correction of vertebral deformity with high safety， which is worth of clinical recommendation.