Abstract: Pulchinenoside D is the most widely and the highest titer monomer of many effective monomer components of Baitouweng in antitumor researches， which is one of the research hotspots of antitumor drugs in recent years. Pulchinenoside D inhibits tumor survival by inhibiting proliferation and promoting apoptosis of tumor cells， inhibiting energy metabolism， regulating autophagy and inhibiting tumor cell migration and metastasis. In this review， we collected related studies on antitumor of pulchinenoside D in recent years， which may provide new ideas for tumor treatment.

Key words: Tumor, Pulchinenoside D, Apoptosis, Autophagy