Abstract: Resently， many studies have shown that different circRNA can act as a special noncoding RNA which binds to specific miRNAs to play sponge activity. Through this way can inhibit miRNA function， and also affect the relevant pathways and the occurrence and development of specific tumors. The biogenesis， properties and functions of endogenous circulatory sponges were summarized by collecting experimental studies， and the effects of circRNA sponge and human tumor development were reviewed.

Key words: Cyclic RNA（circRNA）, Biomarker, Review