乳腺癌;脑转移;分子亚型;临床特征;治疗," /> 乳腺癌;脑转移;分子亚型;临床特征;治疗,"/> Brain metastasisMolecular subtypesClinical characteristicsTreatment,"/> <span style="font-family:'Calibri','sans-serif';font-size:10.5pt;">Progress of characteristics and treatment of breast cancer brain metastasis</span>

Chinese Clinical Oncology ›› 2022, Vol. 27 ›› Issue (03): 265-272.

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Progress of characteristics and treatment of breast cancer brain metastasis

  

  1. Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing UniversityGeneral Hospital of Eastern Theater Command, PLA, Nanjing 210002, China
  • Received:2021-06-01 Revised:2021-12-30 Online:2022-03-25 Published:2022-05-12

Abstract: In the progression of breast cancer, brain metastasis will occur in 15% to 30% patients. Due to the prolonged survival of breast cancer patients, the incidence of brain metastasis is gradually increasing. The incidence and characteristics of brain metastasis from breast cancer of different molecular subtypes are different. Current treatment for breast cancer brain metastasis includes local treatment and systemic treatment. In recent years, with the development of comprehensive treatment of breast cancer, the application of chemotherapy, endocrine therapy and molecular targeted therapy in breast cancer brain metastasis has received more and more attention. Many new treatment methods such as conjugated drugs, immunotherapy and other methods have also shown certain effects on breast cancer brain metastasis. This article reviews the clinical characteristics and treatment progress of different molecular subtypes of breast cancer brain metastasis, and aims to provide certain ideas and basis for the clinical diagnosis, treatment and management of breast cancer brain metastasis.

Key words: Breast cancerBrain metastasis">;Brain metastasisMolecular subtypes">;Molecular subtypesClinical characteristics">;Clinical characteristicsTreatment')">">;Treatment

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