Chinese Clinical Oncology

The anticancer effect of lobaplatin on human nasopharyngeal carcinoma cells in vitro

TIAN Ying， CHEN Xinggui， HUANG Ying， HUANG He， ZHAO Yuanyuan， LIN Tongyu

Chinese Clinical Oncology. 2013, 18 (4): 289.

Abstract ( 1527 )

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Objective To investigate the anticancer effect of lobaplatin on human nasopharyngeal carcinoma（NPC） in vitro and the probable mechanisms to determine whether lobaplatin is a candidate for chemotherapy in human NPC.
Methods Three kinds of poorly differentiated human NPC cell lines CNE2， HONE1 and SUNE1 were engaged in this experiment. Cytotoxicity of lobaplatin in the cell lines was examined with CCK-8 cell viability assay. Cell cycle and apoptosis were determined by flow cytometry and the expressions of its related proteins were examined by Western blotting analysis.
Results Lobaplatin with different concentration showed evident inhibitory effect on the three kinds of poorly differentiated human NPC cell lines and there was increased in a concentration dependent manner. The proliferation of human NPC cell lines CNE2， HONE1 and SUNE1 were inhibited when they were treated with lobaplatin for 48h. The half maximal inhibitory concentration（IC₅₀） of three kinds of NPC cell lines CNE2, HONE1 and SUNE1 were （4.05±0.49）μmol/L，（4.32±1.17）μmol/L and （2.51±0.15）μmol／L，respectively. Lobaplatin arrested cell cycle progression in G₂ phase with increasing cyclin B1 and phospho-cdc2（Tyr15） proteins in lower doses， however， induced apoptosis with caspase3 cleaved in higher doses. Conclusion Lobaplatin shows anticancer effect on human NPC cells by means of cell cycle blockage and induction of apoptosis, which will contribute to the potential use of lobaplatin in the treatment of human NPC.

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The inhibitory effects and mechanisms of crocin on human lung adenocarcinoma cell line SPC-A1

WANG Xinxing， YU Zhenghong， SHI Shujing， ZHANG Youwei， ZHANG Luo.

Chinese Clinical Oncology. 2013, 18 (4): 295.

Abstract ( 1446 )

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Objective To investigate the potential antiproliferative and proapoptotic effects of crocin on human lung adenocarcinoma cell line SPCA1 and explore its possible anticancer mechanism. Methods Different doses of crocin （1，2，4，8，16mg／ml） were added to the SPC-A1 cells. The MTT assay was performed to reveal the inhibitory effect on cell proliferation. Inverted microscope was used to observe the morphological changes of the SPCA1 cells. Flow cytometry using annexin V-FITC／PI staining was employed to measure the cell apoptosis and cell cycle.RTPCR was used to detect mRNA expressions of p53， Bax and Bcl-2. Results Crocin treatment inhibited the proliferation and induced the apoptosis of SPC-A1 cells in a dosedependent manner. After being treated by crocin for 48h，evident morphological changes including membrane shrinking，rounding shapping and budding to form apoptotic characters were observed. Flow cytometry showed the proportion of SPC-A1 cells increased at G₀／G₁phase while it decreased at S and G₂／M phases，indicating SPC-A1 cells were arrested at G₀／G₁phase by crocin treatment at 48h. The expressions of p53 and Bax mRNA were upregulated，and the expression of Bcl2 mRNA were downregulated in a dose-dependent manner. Conclusion Crocin can inhibit the proliferation of lung adenocarcinoma cell line SPCA1 through inducing cell cycle arrest and apoptosis， with the possible mechanism of dysregulation of p53， Bcl-2 and Bax expression.

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The sonodynamic effects of sonoflora on S180 sarcoma in mice

LIN Jianguang， ZHANG Weimin， WANG Xiaohuai， LUO Yifan，HAO Jiandong，WANG Jinjing

Chinese Clinical Oncology. 2013, 18 (4): 300.

Abstract ( 1398 )

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Objective To explore whether sonoflora， a sonosensitizer， can accumulate selectively in the S180 sarcoma of mice and to assess its antitumor effects of sonodynamic therapy（SDT）. Methods S180 sarcoma tumorbearing mice received intraperitoneal injection of 10mg／kg of sonoflora and were respectively sacrificed on 3h， 6h， 12h， 18h， 24h， 48h， 72h. Sonoflora gathered in the tumor and normal muscle tissues was observed by confocal microscopy. Tumorbearing mice were treated with ultrasound， sonoflora and ultrasound combined with sonoflora treatment， respectively. The blank control group was received intraperitoneal injection of saline solution. Tumor size was measured every 2 days and then tumors were stripped for weight comparison on 15th day. Results The sonoflora content of the tumor tissues was 5.33 times higher than that of the normal muscle tissues at its peak at the 18th hour after intraperitoneal injection， and the difference was the most obvious. It was the best time for SDT. Ultrasound alone（0.4W／cm²， 0.8W／cm²， 1.6W／cm²）or sonoflora alone（10mg／kg，20mg／kg，40mg／kg）had exhibited no significant effects on tumor size and tumor weight. The weight of tumor tissues in sonoflora（10mg／ml）combined with ultrasound with 0.4W／cm²（S1U1），0.8W／cm²（S1U2），1.6W／cm²（S1U3）were （2.30±0.40）g，（0.94±0.44）g and （0.88±0.28）g，respectively. The weight of tumor tissues in S1U1, S1U2 and S1U3 was less than that of control group，ultrasound alone and sonoflora alone group. There were significant statistical differences（P＜0.05）. The weight of tumor tissues in S1U1 group had statistical differences from that of S1U2，S1U3 group（P＜0.05）. There were no statistical differences between S1U2 and S1U3 group（P＞0.05）. Conclusion Sonoflora has the ability of special accumulation targeting to tumor， and ultrasound combined with sonoflora has significant damaging effect on S180 sarcoma.

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The detection of RET fusion gene in nasopharyngeal carcinoma

ZHANG Jing， HUANG Peiyu， YAN Yue， ZHANG Li.

Chinese Clinical Oncology. 2013, 18 (4): 305.

Abstract ( 1416 )

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Objective To screen the expression of RET fusion gene in nasopharyngeal carcinoma specimens and cell lines.
Methods RET fusion gene in tissue microarray and cell lines were detected by fluorescence in situ hybridization （FISH） and reverse transcription polymerase chain reaction （RT-PCR）. Results One hundred and thirtyseven cases of nasopharyngeal carcinoma tissues and 6 strains of common nasopharyngeal carcinoma cell lines were screened by fluorescence in situ hybridization. However， no RET fusion gene were found in nasopharyngeal carcinoma specimens and cell lines， and further RT-PCR examination of KIF5B／RET fusion gene proved the same. Conclusion There is no RET fusion gene in nasopharyngeal carcinoma， suggesting RET oncogene does not play a leading role in the development of nasopharyngeal carcinoma. RET oncogene may be not a suitable target in the treatment of nasopharyngeal carcinoma， which prompts the existence of other molecular mechanism in the occurrence and development of nasopharyngeal carcinoma. A genomewide analysis of nasopharyngeal carcinoma is quite essential for understanding the unique biological features of nasopharyngeal carcinoma.

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Clinical and prognostic significances of VEGF， HIF-1α and TGF-β1 expressions for postoperative gastric cancer patients with stage Ⅰ-Ⅲ

SHI Yan， CHEN Li， WANG Zhikuan， YUAN Jing， WANG Lingxiong， DAI Guanghai.

Chinese Clinical Oncology. 2013, 18 (4): 310.

Abstract ( 1397 )

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Objective To explore the expressions of vascular endothelial growth factor（VEGF）， hypoxiainducible factor-1 α（HIF-1α） and transforming growth factor-β1（TGF-β1） and clinical and prognostic significances in stage Ⅰ-Ⅲ postoperative gastric cancer. Methods The cases that received radical surgery in Chinese PLA General Hospital from Jan. 2004 to Dec. 2006 and diagnosed with stage ⅠⅢ gastric cancer were collected. Paraffinembedded samples of those cases were collected to detect expressions of VEGF， HIF-1α and TGF-β1 by immunohistochemical method and tissue chips. The expressions of VEGF, HIF1α and TGFβ1 and their relationships with clinico pathological characteristics and prognosis were analyzed.
Results In a total of 343 cases, the positiveexpression rates of VEGF， HIF-1α and TGF-β1 were 49.3％， 30.9％ and 39.1％， respectively. And the expressions of VEGF， HIF-1α and TGF-β1 were pairwise correlated（P＜0.05）. After a median followup of 70.0 months， 232 patients experienced metastatic or recurrent tumors and 218 patients died. The median disease free survival（DFS） was 23.0 months and the median overall survival time（MST） was 31.1 months. Univariate analysis showed that， age＜60， partial gastrectomy， without signet ring cell cancer， lauren intestinal type， negative cancer embolus， tumor diameter ＜5cm， earlier TNM stage， received adjuvant chemotherapy，VEGF negativeexpression or HIF1α negativeexpression predicted better DFS and OS， respectively， compared with the matching groups for each above. In addition， all of three biomarkers（VEGF, HIF-1α, TGF-β1） coexpression was significantly correlated with worse DFS（8.6 months） and OS（17.7months）， compared with any two biomarkers co-expression， anyone biomarker expression or all of three biomarkers negativeexpressions（P＜0.05）， respectively. Cox multivariate analysis showed that expressions of HIF-1α and VEGF were also independent risk factors in predicting DFS and OS， after taking the TNM stage， gastrectomy method and adjuvant chemotherapy into account（P＜0.05）. ConclusionThe positiveexpressions of VEGF and HIF-1α can be both considered as poor prognostic factors of DFS and OS for postoperative gastric cancer patients with stage Ⅰ-Ⅲ.

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Preliminary study of discrimination between benign and malignant breast lesions by using acoustic radiation force impulse imaging

ZHANG Yan， CHEN Cuijing， SHI Xiuyun， LIU Xing， LIU Jia.

Chinese Clinical Oncology. 2013, 18 (4): 317.

Abstract ( 1094 )

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Objective To evaluate the feasibility and the diagnostic value of acoustic radiation force impulse （ARFI） in discriminating benign from malignant breast lesions. Methods The virtual touch tissue quantification（VTQ） values were analyzed in 146 patients with 150 breast lesions. All breast lesions were confirmed through surgery or biopsy pathology. The cutoff values were determined by an analysis of receiveroperating characteristic（ROC） curve using pathology as the golden criteria. Results There were 55 benign lesions and 95 malignant lesions in 150 lesions. The VTQ value of benign and malignant breast lesions were (2.05±1.58)m/s and (6.94±2.11)m/s, respectively. There was significant difference in the VTQ value between benign and malignant breast lesions（P＜0.05）.The areas under ROC curves was 0.811（95％CI： 0.740-0.883）.The cut off point of VTQ value was determined as 2.5m／s， and the sensitivity， specificity and accuracy were 79％， 71％ and 75％.The cut off point of VTQ value was determined as 28m／s in those more than 8mm breast lesions， and the sensitivity， specificity and accuracy were 90％， 82％ and 85％.
Conclusion ARFI can provide new quantitative elasticity information of breast lesions， which is a new helpful method in discriminating benign from malignant breast lesions，especially in those more than 8mm breast lesions.

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Diagnostic value of color doppler ultrasound for papillary thyroid carcinoma

PENG Juan， WU Min， ZHANG Jie， GONG Li， JIN Zhibin， YANG Jian

Chinese Clinical Oncology. 2013, 18 (4): 321.

Abstract ( 1267 )

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ObjectiveTo explore the diagnostic value of color doppler ultrasound for papillary thyroid carcinoma（PTC）. Methods One hundred and fifteen cases with PTC and 129 cases with thyroid benign mass who were confirmed by pathology were analyzed comparatively with color doppler ultrasound. The chisquare test and multivariate logistic regression analysis were used to identify the prognostic factors. Results The sensitivity and specificity of ultrasound for the diagnosis of PTC was 82.07％ and 86.75％. PTC could be diagnosed according to features detected by ultrasound，including mass shape， boundary， echo， calcification and so on. The sensitivity of boundary and echo was 87.20％ and 84.80％；and the specificity of aspect ratio and microcalcification was 92.59％ and 86.75％. The result of χ2 analysis was meaningful ultrasonic features including mass shape， boundary， echo and microcalcification. The result of Logistic regression analysis was echo and microcalcification with significant differences in the prognostic factors in PTC. The odd ratio（OR） of echo was 3.13（95％CI： 1.58-6.19，P=0.001）.The OR of microcalcification was 2.03（95％CI： 1.19-3.48， P=0.02）.
Conclusion Two dimensional ultrasound is basic examination in diagnosis of PTC， microcalcification and low echoes in high frequency ultrasonography may be an important diagnostic indicator for PTC， which can be useful in differentiating PTC from benign thyroid mass.

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Study of HPV genotypes distribution of Han and Uighur women with cervical cancer and cervical lesions in Xinjiang

GULINAER Abula， ZHU Kaichun， MAYINUER Niyazi， MA Zhenghai.

Chinese Clinical Oncology. 2013, 18 (4): 325.

Abstract ( 1244 )

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Objective To investigate human papilloma virus（HPV） prevalence and HPV genotypes distribution of cervical carcinoma and cervical lesions patients in Uygur and Han， and analyze their differences between two ethnic groups.
MethodsThe cervical samples of 224 Uighur and Han women（ratio of Uygur to Han was 1∶1）， who visited Xinjiang Uighur Autonomous Region Peoples Hospital during the November 2011 to May 2012， were selected. Flowthrough hybridization and gene chip technique were used to detect 21 kinds of HPV genotypes. Results Eighteen kinds of different subtypes were detected， HPV16 was the most common type in both Han and Uighur people； 18 kinds of different subtypes were detected in cervical lesions and 8 in cervical cancer. HPV subtypes tended to be focused on along with the upgrade of the cervical lesions，these subtypes which were tend to be focused on in two nations was HPV16， 18， 52， 58， 53, 39. There was no significant difference in the detection rates of these HPV genotypes between two nations（P＞0.05）. The multiple HPV infection rates were 22.13％（27／122） and 34.43％（42／122）in cervical cancer and cervical lesions patients in Uighur and Han, respectively. There were significant differences between two nations（P＜0.05）. Conclusion There are some differences between Han women and Uighur women for HPV genotypes. The multiple HPV infection rates of cervical cancer and cervical lesions in Uighur females are higher than Han females. It suggests that the rate of the multiple HPV infection might be the one of the reasons why cervical cancer incidence in Uighur significantly is higher than Han in Xinjiang.

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Analysis of the status and trends of prostate cancer incidence in China

HAN Sujun， ZHANG Siwei， CHEN Wanqing， LI Changling.

Chinese Clinical Oncology. 2013, 18 (4): 330.

Abstract ( 2006 )

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Objective To investigate the status and trends of prostate cancer incidence in China. Methods The registered prostate cancer data between 1998 and 2008 from the National Cancer Registration Center was collected， including the incidence of prostate cancer， the cumulative probability of developing prostate cancer of males aged 0.74， composition and agespecific incidence. The status and trends of the incidence between urban and rural men was compared and analyzed. Results In 2008， the incidence of prostate cancer of Chinese men was 11.00／100 000， accounting for 3.33％ of the incidence of mens malignant tumors. The worlds population agestandardized incidence rate was 6.73／100 000. The cumulative risk of males aged 0.74 was 0.70％. The incidence of urban males was about 3.7 times of that in rural areas. The results of agespecific incidence showed that the incidence of Chinese males over the age of 70 ranked the first place in the males genitourinary tumor. The average annual growth rate during 19982008 was 12.07％. The growth incidence rate of urban men with prostate cancer was 8.53/100 000, higher than 2.53/100 000 in rural areas. But the average annual growth rate of urban males was 11.25%, lower than 13.28% of rural males. The proportion of high age group was increased significantly in the age composition of the incidence over time. Conclusion In recent years， the incidence of prostate cancer have showed an obvious growth trend in China. Prostate cancer is becoming urinary tract malignant tumor that impacts Chinese mens health seriously.

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The efficacy of pain treatment and quality of life in lung cancer survivors under the model of medical institutioncommunity referral

ZHAO Libo， ZHANG Ying， GUO Hongwei， ZHOU Weiguo， WANG Yuzhou， LIU Duanqi， LIU Hua

Chinese Clinical Oncology. 2013, 18 (4): 335.

Abstract ( 1074 )

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Objective To observe the clinical efficacy and adverse reactions of oxycodone hydrochloride controlledrelease tablets for lung cancer survivors with moderate and severe pain， and evaluate the influences on the quality of life under medical institutionscommunity medical service mode.
Methods Sixty-three lung cancer patients with moderate and severe pain were enrolled. The numerical rating pain rating（NRS） and the European Organization for Research and Treatment of Cancer（EORTC） QLQ-C30 questionnaire were employed to evaluate the pain degree and quality of life before and after the treatment of oxycodone hydrochloride controlledrelease tablets. Then community physicians would be in charge of subsequent treatment， including pain treatment， psychological intervention and follow-up. EORTC QLQ-C30 questionnaire was employed and a comparative analysis was conducted 4 weeks later. Results After analgesic treatment， the overall response rate of pain was 90.5％. The remission rates in moderate and severe pain were 94.1％ and 86.2％, respectively. The main adverse reactions including nausea， vomiting and constipation were relieved or disappeared after proper treatment. The social function， emotional function， physical function， role function, pain， insomnia and overall quality of life were significantly improved after analgesic treatment（P＜0.05）. Compared with the pretreatment， the overall quality of life in both moderate and severe pain group were statistically improved（P＜0.05）. And the psychological intervention could effectively improve the qualite of life（P＜0.05）. Conclusion The analgesic therapy with oxycodone hydrochloride controlledrelease tablets can effectively relieve the pain and improve the qualite of life in lung cancer patients. Establishing an effective comprehensive psychological intervention in medical institutionscommunity health service model can effectively improve the qualite of life for lung cancer survivors.

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Analysis of clinical efficacy in 92 patients with laryngeal carcinoma

LIAO Feng， QIN Shukui，GONG Xinlei，WANG Lin，ZHANG Yu，CHEN Yingxia，LIU Xiufeng，HUA Haiqing.

Chinese Clinical Oncology. 2013, 18 (4): 340.

Abstract ( 1112 )

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Objective To investigate the objective efficacy， survival benefit, safety and the importance of preservation of the larynx organ functional in Chinese patients with laryngeal carcinoma by different means of treatment.
MethodsThe data of 92 cases of laryngeal cancer patients treated in 81 Hospital of PLA from January 2000 to May 2012 were analyzed retrospectively. All patients were divided into chemoradiotherapy group， surgical treatment group and the operation combined with chemoradiotherapy group. The treatment， survival time and the quality of life（QOL） of different treatment groups were compared and analyzed.
ResultsNinetytwo cases of laryngeal cancer patients with chemoradiotherapy group in 39 cases， 20 cases in surgical treatment group， 33 cases in the operation combined with chemoradiotherapy group. The 12 patients of stage Ⅳ in chemoradiotherapy group received PF regimen， NP／NF regimen， paclitaxelbased chemotherapy and Chinese medicine Fufang Hongdoushan capsule combined with radiotherapy of throat or cetuximab treatment. Of 12 patients in stage Ⅳ， One patient achieved CR， with PR in 3 cases， SD in 6 cases， PD in 2 cases. The response rate（RR） was 33.3％（4／12） and the disease control rate（DCR） was 83.3％（10／12）. QOL was improved in 7 cases， stable in 4 cases， only 1 case of deterioration. Improvement and the stable rate was 916％. The main toxicity of chemotherapy and radiotherapy in 12 patients were grade 3 of nausea and vomiting in 1 case， grade 3 of leucopenia in 3 cases， grade 3 of thrombocytopenia in 1 case. There were no grade 4 toxicity reaction. By KaplanMeier method， the median overall survival time of 92 patients with laryngeal carcinoma was 60 months. The median overall survival time was 72 months in the chemoradiotherapy group, 90 months in the surgical treatment group and 58 months in the operation combined with chemoradiotherapy group. There were no statistical differences among the three groups（P＞0.05）. Fiftythree of operation patients had obvious pronunciation dysfunction， even lost the pronunciation function， needed permanent tracheostomy and quality of life was reduced. Conclusion Chemotherapy or combined with molecular targeted drugs in the treatment of laryngeal cancer has a good efficacy and toxicity can be tolerated. For a considerable part of the patients， it can replace operation， or reduce the scope of operation and the damage.

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Effect of the optimal timing of radiotherapy on the concurrent chemoradiotherapy for locally advanced nonsmall cell lung cancer

WU Xiaojin， MI Yanyan， HU Ankang， WANG Wei， DONG Haibei， SANG Chunli， FENG Sumei， YIN Yongmei

Chinese Clinical Oncology. 2013, 18 (4): 344.

Abstract ( 1050 )

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Objective To explore the efficacy and safety of concurrent chemoradiotherapy with different timing of radiotherapy for locally advanced nonsmall cell lung cancer（NSCLC）. Methods Sixty NSCLC patients were randomly divided into four groups. All the patients received chemotherapy first（paclitaxel 120mg／m2iv d1, d8; cisplatin 75-80mg／m²ⁱv d₁). Twentyone days was a cycle， and 4 cycles were applied. And then combined with radiotherapy（1.8-2.0Gy／f，once per day，five times per week，DT 60Gy） in the treatment after the first cycle（group A）， the second cycle（group B）， the third cycle（group C） and the fourth cycle（group D） respectively. The efficacy and side effects were observed among four groups. Results The efficacy of the four groups was 92.3％， 71.4％， 60.0％ and 46.7％. The main side effects were radioactive esophagitis， myelosuppression， fatigue and alopecia. The incidence rate of grade 3-4 side effects in group A was higher than those of other groups， and had significant difference compared with group C and group D. Conclusion Radiotherapy combined with chemotherapy at early stage can achieve better effect companied by higher side effects in the treatment of locally advanced NSCLC. The therapeutic regimen should be considered in clinic.

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Comparison study of elemene injection， TP regimen combined with radiotherapy in the treatment of esophageal cancer

LIU Xiangyang， XIA Xiaochun， DING Hua， WU Zhijun， LIU Jibin.

Chinese Clinical Oncology. 2013, 18 (4): 348.

Abstract ( 1234 )

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Objective To evaluate the efficacy and side effects of elemene injection combined with radiotherapy compared to TP regime（paclitaxel+nedaplatin） combined with radiotherapy in the treatment of esophageal cancer.
MethodsOne hundred and twentyfive patients diagnosed as esophageal cancer from December 2006 to December 2009 were randomly divided into three groups: radiotherapy group（RT group， n=45）， radiotherapy combined with elemene injection group（RT+E group， n=42） and radiotherapy combined with TP regimen group（RT+TP group， n=38）. Conventional radiotherapy and threedimensional conformal radiotherapy were applied for patients， and the protocol was 2.0Gy／f, 5f/week， DT 60-66Gy. Chemotherapy drugs were taken as follow： elemene injection 400mg／d iv d₁-d₂₁， paclitaxel 150mg／m² iv d₁； nedaplatin 50mg／d iv d₁-d₃. The patients of RT+TP group received a course of TP regimen chemotherapy primarily， then started to receive radiotherapy after relevant examinations. The number of white blood cell（WBC） of the patients was detected and the change of WBC was analyzed every week within the first four weeks in the process of radiotherapy. The side effects and shortterm efficacy of each group were evaluated after radiotherapy. The patients were followed up， then we calculated the survival rate of 1-3 year and drew the KaplanMeier survival curve. Results The response rate of RT group, RT+E group and RT+TP group were 84.4％， 90.5％ and 92.1％, respectively. The incidence rates of the radiation esophagitis were 66.7％， 61.9％ and 60.5％, respectively. The incidence rates of the radiation pneumonitis were 24.4％， 31.0％ and 28.9％, respectively. The incidence rate of the myelosuppression in three groups was 100.0%. There were no significant differences in shortterm efficacy and side effects including radiation esophagitis， radiation pneumonitis and myelosuppression， when three groups compared with each other（P＞0.05）. There was significant increase in the change of WBC when RT+E group compared with the other two groups from the first week to the fourth week in the progress of radiotherapy（P＜0.05）. The oneyear survival rates of the RT group, RT+E group and RT+TP group were 60.0％， 73.8％ and 78.9％； two-year survival rates were 40.0％， 54.8％ and 60.5％； three-year survival rates were 28.9％， 33.3％ and 44.7％, respectively. There were no siginificant differences on the survival rates among 3 groups（P＞0.05）. Conclusion The two combination regimens have similar shortterm efficacy and don't increase the side effects of radiotherapy. In the process of radiotherapy， elemene injection has prominent role on the maintainence of WBC level of patients.

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Clinical observation of methotrexate， cisplatin， adriamycin and ifosfamide for stage ⅡB extremity osteosarcoma

HU Beibei， TANG Lina， ZHENG Shuier， SUN Yuanjue， SHEN Zan， LIN Feng， YAO Yang

Chinese Clinical Oncology. 2013, 18 (4): 353.

Abstract ( 1066 )

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Objective To investigate the efficacy and side effects of two combinations of highdose methotrexate（MTX）， cisplatin（DDP）， adriamycin（ADM） and ifosfamide（IFO） in the treatment of extremity osteosarcoma patients with stage ⅡB. Methods A retrospective analysis was conducted for 185 osteosarcoma patients treated with the four drugs mentioned above. Ninety three patients received the Italian therapeutic scheme IOR-OS／N-5（MTX 812g／m²iv 6h，d₁，CF 15mg at one time，12 times；DDP 80-100mg／m²，ADM 60mg／m² iv，d8；IFO 20g／m2iv d21d25，mesna 400mg after IFO for 0，4，8h）and the remaining 92 patients received the therapeutic scheme optimized（MTX 812g／m2iv 6h，d1，CF 15mg at one time，12times；DDP 80-100mg／m² iv，d₈；ADM 60mg／m² iv d₂₁，IFO 2.0g／m²iv d₂₁-d₂₅，mesna 400mg after IFO for 0，4，8h）. To compare the efficacy and side effects of two therapeutic schemes. Results The limb salvage rates of IOROS／N-5 and optimized schemes were 52.7％（49／93）and 58.7％（54／92）， respectively. The 3-year recurrence rates of IOR-OS／N-5 and optimized schemes were 14.0％ and 7.6％，respectively. The 3-year metastasis rates of IOR-OS／N-5 and optimized schemes were 47.3％ and 30.4％， respectively. The 3-year survival rates of IOR-OS／N-5 and optimized schemes were 57.0％ and 75.0％ with statistical significance（P＜0.05）. The median diseasefree survival times of two groups were 22.2 months（95％CI：16.2-28.2）and 29.0 months（95％CI：23.8-34.3），respectively. There was statistical significance（P=0.024）.The median overall survival times of two groups were 32.2 months（95％CI：23.2-38.2） and 36.1 months（95％CI：33.8-44.3），respectively. There was statistical significance（P=0.032）. The main side effects were liver function damages， myelosuppression， nausea and vomiting and so on. The incidence rate of liver damage with grade 3-4 accounted for 35.2％ and 16.6％ in IOR-OS／N-5 and optimized scheme groups， respectively. Grade 3-4 neutropenia accounted for 22.6％ and 30.2％ in two groups， respectively. Conclusion Optimization of highdose MTX， DDP， ADM and IFO based on the Chinese patients body condition increases the resistance and efficacy in the treatment of osteosarcoma.

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Depression and correlating factors in advanced cancer patients

YE Mei， FENG Zhengzhi，LIU Keyu， CHEN Huoming.

Chinese Clinical Oncology. 2013, 18 (4): 357.

Abstract ( 1219 )

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Clinical observation of cetuximab plus chemotherapy in the treatment of advanced gastric cancer

XIAO Xiaoyi， DAI Guanghai， SUN Qiong， SHI Yan， WU Qian.

Chinese Clinical Oncology. 2013, 18 (4): 361.

Abstract ( 1222 )

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Objective To investigate the efficacy and side effects of cetuximab plus chemotherapy in treatment of advanced gastric cancer. Methods Thirteen patients with advanced gastric cancer were treated with cetuximab plus traditional chemotherapy. Cetuximab 400mg／m² was taken at the first dose and a maintenance dose was 250mg／m² every week. The curative effects were evaluated after 2-3 cycles. Results Out of the total 13 patients， 6 cases received first-line treatment， 2 with PR， 4 with SD； seven cases received multichemotherapy treatment， 1 with PR， 2 with SD， 3 with PD， and 1 case could not be evaluated. The main toxic reactions were myelosuppression, digestive tract reaction and skin and mucosa reactions. Until the deadline date（December 30， 2012）， two of the 13 patients survived， and 11 patients died. The survival time ranged from 3.9 to 40.8 months， and the median survival time was 16.4 months （95％ CI： 8.4-20.4）. Conclusion Cetuximab plus chemotherapy in the treatment of advanced gastric cancer may have good efficacy and toxicity can be tolerate

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Clinical observation of relapsed primary central nervous system lymphoma in 17 patients

WANG Yong， LIU Baoyan， XU Dezhi， ZHU Yufang， XUJun， TAO Rongjie.

Chinese Clinical Oncology. 2013, 18 (4): 364.

Abstract ( 1134 )

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Objective To explore the clinical manifestations， imaging features， treatment effects and prognosis of relapsed primary central nervous system lymphoma. Methods Seventeen cases with relapsed primary central nervous system lymphoma treated in our hospital from June 2008 to June 2012 were retrospectively reviewed. Seven relapsed PCNSL patients were treated with highdose pemetrexed（900mg／m²）. Ten relapsed PCNSL patients were treated with temozolomide， nedaplatin and vincristin regimen, in addition， 3 of them were treated with local radiotheraphy with 2030Gy, 3 patients were treated with Ommaya reservoir placement and ventricular therapy with rituximab（30mg） through Ommaya reservoir were given after operation.
ResultsIn 17 patients, ectopic recurrence was found in 9 （52.9％）， recurrence in situ in 5 （29.4％）， leptomeningeal metastasis in 2 （11.8％）， lumbar vertebrae metastasis in 1 （5.9％）. Magnetic resonance spectroscopy showed Cho peak elevated and NAA, Cr peak declined in the solid area and peritumoral edema region, lip peak appeared obviously in the solid area. Complete remission in 6 of 17（35.3％）， partial remission in 4 of 17（23.5％） patients， stable disease in 5 of 17（29.4％）， progressive disease in 2 of 17（11.8％）， and overall response rate was 58.8％（10／17）. The median overall survival was 111 months from recurrence to death. There was no significant difference between temozolomidebased chemotherapy and pemetrexed chemotherapy（P＞0.05）. Conclusion Ectopic recurrence was the most common relapse pattern in relapsed PCNSL. The prognosis of relapsed PCNSL is very poor. The chemotherapy regimen with good efficacy and less side effects needes to be explored. But it is still needed to expand samples and increase cooperation of multicenter study， and the combined treatment with temozolomicle or pemetrexed is a meaningfull trial.

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Progress in the studies of multiplehit lymphoma

YANG Bohan， LIU Hongli， WU Gang

Chinese Clinical Oncology. 2013, 18 (4): 368.

Abstract ( 1013 )

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Multiple-hit lymphoma is a heterogeneous disease classified as Bcell lymphomas， unclassifiable， with features intermediate between diffuse large Bcell lymphoma and Burkitt's lymphoma. It is characterized by worse overall survival， extremely poor prognosis， and easy to relapse. Here is to review the most recent research on molecular genetics， epidemiology， clinical feature， histopathology， immunophenotype， treatment and prognosis of multiplehit lymphoma.

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The advances on interstitial lung disease associated with molecular targeted drugs

WANG Hui， ZONG Xiaofu

Chinese Clinical Oncology. 2013, 18 (4): 372.

Abstract ( 990 )

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Tumor targeted drugs possess distinct effect of targeted antitumor， which have played an important role in recent clinical therapy and displayed satisfactory prospect.With the continuous enlargement of application range of targeted drugs， interstitial lung disease associated with them is reported more and more frequently. The pathogenesis and standardized treatment guidelines of interstitial lung disease associated with targeted drugs remain unknown. Immediate withdrawal of tumor targeted drugs， intravenous corticosteroid hormones and oxygen therapy is current recommended management.

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rogress of CXC chemokines and their receptors in breast cancer

WANG Yunxuan，ZHAO Hong，ZHANG Qingyuan

Chinese Clinical Oncology. 2013, 18 (4): 377.

Abstract ( 1016 )

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Chemokines and their receptors have a multifaceted role in tumor biology and are closely related to tumor occurrence， progression and metastasis. CXC chemokines and their receptors have clearly become the focus of attention， because they can regulate tumor biological behavior through a series of mechanisms. The complex roles of CXC chemokines and their receptors with high attention in breast cancer will be reviewed briefly in this paper.

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标准刊号：	ISSN 1009-0460
	CN 32-1577/R