Chinese Clinical Oncology

Expression of Kif2c in non-small cell lung cancer and its clinical significance

SONG Shilong，BI Minghong，WANG Hongya，GAO Zhenyuan

Chinese Clinical Oncology. 2016, 21 (6): 481.

Abstract ( 538 )

PDF（pc） (1317KB) ( 350 )

Save

Objective To explore the expression and clinical significance of Kif2c in non-small cell lung cancer （NSCLC）. Methods Specimens containing 62 surgically resected NSCLC tissues and 30 paracancerous tissues were selected from the First Affiliated Hospital of Bengbu Medical College. Immunohistochemical staining was applied to detect the expression of Kif2c in NSCLC tissues and paracancerous tissues. The relationship between clinical characteristics and Kif2c expression was also studied. Results The high-expression rate of Kif2c in NSCLC tissues was 75.8% （47/62）， higher than 26.7% （8/30） of paracancerous tissues with significant difference （P<0.05）. The expression of Kif2c protein was closely related to the clinical stage and lymph node metastasis of NSCLC. The high-expression rate of Kif2c in clinical stage Ⅲ was significant higher than those of stage Ⅰ-Ⅱ in NSCLC tissues （P<0.05）. The high-expression rate of Kif2c in lymph node metastasis was significant higher than those without lymphnode metastasis （P<0.05）. The high-expression rates of Kif2c protein in NSCLC had no relationship with sex，age， tumor size，grade and organization type（P>0.05）. Conclusion Kif2c may play an important role in the occurrence and development of NSCLC. Kif2c can be a molecular target of NSCLC.

Related Articles | Metrics

Expression of Cullin 4B in non-small cell lung cancer and its clinical significance and cell function analysis

WEI Zhongsheng， CHEN Hongming， HUANG Yongzhi， LUO Bin

Chinese Clinical Oncology. 2016, 21 (6): 485.

Abstract ( 484 )

PDF（pc） (1607KB) ( 312 )

Save

Objective To explore the expression of Cullin 4B （CUL4B） in non-small cell lung cancer （NSCLC） and its effect on NSCLC cell function. Methods The expression of CUL4B was detected by immunohistochemistry and quantitative realtime polymerase chain reaction （qPCR） in 77 cases of NSCLC tissues and 42 cases of normal tissues adjacent to cancer. The qPCR was used to detect the mRNA level of CUL4B in common NSCLC cell lines， including H358， H460， H1299， A549 and SK-MES-1. The highest expression of the cell lines were transfected with siRNA CUL4B （CUL4B interference group） and CUL4B negative control siRNA （negative control group）， respectively. Transfection efficiency was verified by qPCR. The effect of interfering CUL4B expression on the cell proliferation at 24， 48， 72， 96 h was detected by MTT method. Flow cytometry and Transwell assay were used to detect the effect of CUL4B expression on cell apoptosis and invasion at 48 h. Results The high expression rates of CUL4B protein in NSCLC tissues and adjacent normal tissues were 636% （49/77） and 381% （16/42）， and the difference was statistically significant （P<0.05）. CUL4B expression was related to tumor diameter， lymph node metastasis and clinical stage （P<0.05）， but not related to gender， age， pathological type and histological grade （P>0.05）. The relative level of mRNA CUL4B in NSCLC tissue was 2.713±0.246， and interfering CUL4B expression of NSCLC cell， proliferation ability was significantly decreased， cell apoptosis increased and the invasion and metastasis ability decreased. Conclusion CUL4B protein expression was significantly increased in NSCLC tissues and cell lines， and was related to lymph node metastasis， clinical stage and cell differentiation. Silencing CUL4B can affect the proliferation， apoptosis and metastasis of NSCLC cells.

Related Articles | Metrics

Analysis of plasma OLFM4 level and its clinical significance in patients with non-small cell lung cancer

ZHU Kai， ZHANG Aiping， LIN Xiumin

Chinese Clinical Oncology. 2016, 21 (6): 491.

Abstract ( 498 )

PDF（pc） (958KB) ( 335 )

Save

目的探讨非小细胞肺癌（NSCLC）患者血浆OLFM4水平及其临床意义。方法收集本院确诊的272例NSCLC患者的外周血样本（NSCLC组），采用酶联免疫吸附法检测其血浆OLFM4水平，分析血浆OLFM4水平与临床病理参数（性别、年龄、肿瘤大小、分化类型、临床分期、T分期、吸烟史和淋巴结转移）的关系；选取同期300例健康体检者的外周血样本作对照。检测156例NSCLC组织样本中OLFM4水平，采用Person相关分析法分析组织与血浆中OLFM4水平的相关性。采用受试者工作特征曲线（ROC）评价血浆OLFM4水平在NSCLC早期诊断的效能。结果 NSCLC组血浆中OLFM4水平为（77.39±15.13）μg/ml，高于对照组的（14.56±6.94）μg/ml，差异有统计学意义（P<0.05）；血浆OLFM4水平与NSCLC的肿瘤大小、TNM分期、T分期及淋巴结转移有关，其中肿瘤大小>3 cm、TNM Ⅲ+Ⅳ期、T3+T4期及有淋巴结转移者的血浆OLFM4水平均高于对应项（P<0.05）。NSCLC患者血浆中OLFM4水平与组织中OLFM4表达呈正相关（r=0.641，P<0.05）。血浆OLFM4水平诊断NSCLC的曲线下面积（Az）为0.862（95%CI：0.752～0.937），最佳截断值为2711 μg/ml，该截断值的灵敏度和特异度分别为81.3%和77.4%。结论 OLFM4在NSCLC患者血浆中高表达，与肿瘤大小、临床分期及淋巴结转移有关，可能在NSCLC发生发展中有一定作用；且在NSCLC早期诊断有较好价值。

Related Articles | Metrics

Expression and clinical significance of Th-POK and related factors in gastric cancer tissues

JIANG Chen，JIANG Lili，HUANG Lifang，LI Guohua

Chinese Clinical Oncology. 2016, 21 (6): 495.

Abstract ( 434 )

PDF（pc） (1452KB) ( 289 )

Save

Objective To investigate the expression and clinical significance of Thelperinducing POZ/Krüppel-like factor（Th-POK）CD 4， CD 8， and its related factors RUNX3 and granzyme B（GZMB）in gastric cancer. Methods From March 2011 to October 2014， 100 gastric cancer tissues and adjacent normal tissues were collected. Immunohistochemical PV6000 staining was used to detect Th-POK expression in gastric cancer tissue and normal adjacent tissues， as well as the expression of CD4， CD8， RUNX3 and GZMB protein. The correlation of their expression with clinicopathological features was analyzed. Results The positive expression of Th-POK and CD4 were higher in gastric cancer tissues than those in adjacent normal tissues（80% vs. 67%，P<0.05；77% vs. 60%，P<0.05）. The positive expression of CD8 and RUNX-3 were lower in gastric cancer tissues than those in adjacent normal tissues（80% vs. 60%， P<0.01； 59% vs. 86%，P<0.01）. There was no significant difference of GZMB positive expression rate between gastric cancer tissues and adjacent normal tissue（70% vs. 61%， P>0.05）. The expression of Th-POK and RUNX3 were correlated with TNM stage（P<0.05）， but not with age， tumor site，differentiation and lymph node metastasis（P>0.05）. Th-POK was positively correlated with CD4（r=0200，P<0.05）， and negatively correlated with RUNX3（r=-0373，P<0001）.There was no significant correlation between expression of Th-POK and GZMB or CD8（P>0.05）. Conclusion The expression of Th-POK in gastric cancer tissue is up-regulated， which may interact with RUNX3 to counteract the generation of CD8+ lymphocytes， increases the generation of CD4+ lymphocytes and assists gastric cancer immune escape.

Related Articles | Metrics

Clinical value of combined detection of serum Hcy，CA15-3 and FA in patients with breast cancer

DILIXIATI Jinsihan，TULUHONG Shalieer，ZHAO Qian

Chinese Clinical Oncology. 2016, 21 (6): 500.

Abstract ( 448 )

PDF（pc） (912KB) ( 334 )

Save

Objective To study the clinical value of serum homocysteine（Hcy）， carbohydrate chain antigen 15-3（CA15-3）and folic acid（FA）in breast cancer patients before and after operation or with recurrence and metastasis. Methods From January 2010 to December 2010，387 patients with primary breast cancer who underwent surgery in our hospital were enrolled in this study. The serum levels of Hcy，CA15-3 and FA in breast cancer patients before and after operation were compared. According to the 5-year follow-up data， the patients were then divided into recurrence group（47 cases） and non-recurrence group（340 cases）. The serum levels of Hcy，CA15-3 and FA between both groups were compared. The relationship between FA，CA15-3 and Hcy were analyzed. Results The postoperative serum Hcy and CA15-3 levels were（11.83±4.25） μmol/L and（13.02±3.01） U/ml， both lower than（17.27±6.82） μmol/L and（37.29±15.92）U/ml preoperative，and the postoperative serum FA level was（7.84±3.17） ng/ml， higher than（5.16±2.37） ng/ml with statistical significance（P<0.05）. In recurrence group， postoperative serum Hcy and CA15-3 levels were（16.08±5.93） μmol/L and（28.41±13.85） U/ml， both higher than（11.92±4.31） μmol/L and（14.25±2.96） U/ml of nonrecurrence group， and the postoperative serum FA level was（5.12±2.21） ng/ml， lower than（7.85±3.09） ng/ml of nonrecurrence group with statistical significance（P<0.05）. The abnormal rates of serum Hcy， CA15-3 and FA in recurrence group were higher than those of nonrecurrence group（P<0.05）. As for breast cancer patients with recurrence and metastasis， the abnormal rates of Hcy， CA15-3 and FA in clinical stage III and IV were higher than those of clinical stage I and II period（P<0.05）. The level of FA in patients with breast cancer was negatively correlated with Hcy and CA15-3（r=-0.286 and -0.346， P<0.05）， and Hcy level was positively correlated with CA15-3（r=0.402， P<0.05）. Conclusion The serum CA15-3 and FA levels in patients with recurrent and metastatic breast cancer were higher，and the Hcy level was lower，which can be used to predict the recurrence and metastasis of breast cancer patients.

Related Articles | Metrics

Expression and significance of DNMT1 and p27 protein in primary and secondary glioblastoma multiforme

TAN Chunlei， CHANG Liang， SU Jun， WANG Chao， JIN Hua， LI Guofu， ZHANG Dongzhi， ZHANG Xuexin

Chinese Clinical Oncology. 2016, 21 (6): 504.

Abstract ( 426 )

PDF（pc） (1229KB) ( 313 )

Save

Objective To study the expression and correlation of DNA methyltransferase 1（DNMT1）and p27 protein in primary and secondary glioblastoma multiforme. Methods From Jan 1 2000 to Jan 31 2012， 32 cases of primary glioblastoma multiforme specimens， 32 cases of secondary glioblastoma multiforme specimens and 13 cases of normal brain tissues were enrolled. The expression of DNMT1 and p27 protein was detected in those tissues. Results The positive expression rates of DNMT1 protein in primary and secondary glioblastoma multiforme tissues， as well as in normal tissues were 59.4%，81.3% and 0. The positive expression rates of p27 protein were 50.0%，25.0% and 100.0% in primary and secondary glioblastoma multiforme tissues， and normal brain tissues （P<0.05）. The positive expression of DNMT1 and p27 protein in primary and secondary glioblastoma multiforme tissues had significant difference （P<0.05）. There was no correlation between the expressions of both proteins（r=041，P>0.05）. Conclusion The expression of DNMT1 and p27 protein is different in primary and secondary glioblastoma multiforme tissues. The combined detection of DNMT1 and p27 protein may serve as an index to estimate different types of glioblastoma multiforme.

Related Articles | Metrics

Study of SOD2 gene polymorphism and chemotherapy sensitivity in advanced non-small cell lung cancer

HUANG Jinghui，WANG Tingfeng，CHEN Xin

Chinese Clinical Oncology. 2016, 21 (6): 508.

Abstract ( 449 )

PDF（pc） (911KB) ( 361 )

Save

Objective To investigate the relationship between superoxide dismutase 2（SOD2） gene polymorphism and platinum-based chemotherapy in patients with advanced non-small cell lung cancer（NSCLC）. Methods The polymorphisms of five SOD2 variants（rs7855，rs5746151， rs5746136， rs2758331 and rs4880） were detected by direct sequencing in peripheral blood DNA of 162 patients with NSCLC receiving platinum-based chemotherapy. Among the 162 patients， 43 cases received docetaxe plus cisplatinum regimen，63 cases received gemcitabine plus cisplatinum regimen， and 56 cases received pemetrexed plus cisplatinum regimen. After 2 cycles， the patients were divided into chemotherapy sensitive group（CR+PR）and non-sensitive group（SD+PD） by using the RECIST 1.0 standard. The relationship between different efficacy and clinical pathological parameters， as well as the above polymorphisms were analyzed. Results The frequencies of rs7855， rs5746151， rs5746136， rs2758331 and rs4880 loci in 162 patients with NSCLC were in line with the Hardy-Weinberg equilibrium（P>0.05）. After 2 cycles of chemotherapy， there were 43 cases of PR， 68 cases of SD and 51 cases of PD. The patients were divided into 43 cases of sensitivity group and 119 patients of non-sensitivity group. The sensitivity rate was 26.5%. There was no relation of chemotherapy sensitivity with age，sex，pathological type，clinical stage，ECOG score and chemotherapy regimen. In the rs7855，rs5746151， rs5746136 and rs2758331 sites of SOD2，genotypes and alleles had no significant influence on chemotherapy sensitivity. There were little risks of the mutant allele relative to the wildtype allele or genotype carrying a mutation allele to wild type homozygotes（P>0.05）. The sensitive rates of TT，TC and CC genotypes in SOD2 rs4880 were 42.1%，19.6% and 16.7% with statistical difference（P<0.05）. The sensitive rates of T and C allele were 35.2% and 17.6%，and the difference was statistically significant（P<0.05）. Taking wild type TT as the reference，the risks of less sensitive were increased in TC and CC genotypes（P<0.05）. Taking T allele as the reference， the risk of less sensitive was increased in C allele（P<0.05）. Conclusion SOD2 rs4880 polymorphism is associated with the efficacy of platinum containing regimen in patients with NSCLC. The risk of patients carrying the mutant allele not sensitive to chemotherapy is high， and rs4880 SOD2 polymorphism can be used to predict the efficacy of advanced NSCLC patients receiving platinum-based regimen.

Related Articles | Metrics

Relationship between DNA repair rate and chemotherapy containing alkylating agents for non-Hodgkin’s lymphoma

ZHUANG Yan，GU Kangsheng

Chinese Clinical Oncology. 2016, 21 (6): 514.

Abstract ( 438 )

PDF（pc） (1307KB) ( 334 )

Save

Objective To investigate the relationship between DNA repair rate（DRR） of peripheral blood lymphocyte（PBLC） and the efficacy of combination chemotherapy containing alkylating agents for NHL patients. Methods The DRRs of PBLC in 30 patients with NHL and 20 controls without cancer were detected by single cell gel electrophoresis（SCGE）. The NHL patients received chemotherapy including cyclophosphamide and the efficacy was evaluated after four cycles. In both groups， the DRRs before cyclophosphamide exposure and after exposure followed by restoration were analyzed. The correlation between the DRR of NHL group and the clinicopathological features as well as the efficacy of combined chemotherapy containing alkylating agents was investigated. Results DRRs of the NHL patients were obviously lower than the controls by tail length（Z=4.464， P=0.000） and tail moment（Z=3.828，P=0.000）. The DRRs have no relationship with age，gender，ECOG score，clinical stage，LDH value，Ki-67 proliferation index and drinking habits（P>0.05）. As for 30 NHL patients，there were CR in 4 cases， PR in 14 cases， SD in 10 cases and PD in 2 cases with response rate of 60.0% and disease control rate of 93.3%. To evaluate DRRs with tail length（r=-0.409，P=0.025），it showed that DRRs were negatively correlated with the efficacy of chemotherapy. In addition，no relationship was found between DRRs and efficacy by tail moment（r=-0.224，P=0.234）. Conclusion NHL patients have lower DNA repair capacity than people without cancer. The DRR in PBLCs is correlated negatively with the efficacy of NHL patients treated with alkylating agents.

Related Articles | Metrics

Analysis of the relationship between DNMT3b polymorphism and FOLFOX4 chemotherapy in patients with advanced colorectal cancer

WANG Jianjun， LU Hong

Chinese Clinical Oncology. 2016, 21 (6): 519.

Abstract ( 435 )

PDF（pc） (906KB) ( 382 )

Save

Objective To investigate the relationship between the single nucleotide polymorphisms（SNPs） of DNA methyl transferase 3b（DNMT3b） gene and the efficacy of FOLFOX4 regimen in patients with advanced colorectal cancer. Methods The SNP predictive software was used to screen 4 target SNPs（rs6119954， rs4911107， rs4911259， rs8118663） and 2 SNPs（rs1569686， rs2424913） in the promoter region in the HapMap database of DNMT3b gene in Chinese Han population. The distribution of SNPs in peripheral blood DNA of 178 patients with advanced colorectal cancer were detected by direct sequencing. RECIST 11 standard was used to evaluate the short term efficacy of patients receiving FOLFOX regimen after 4 cycles of chemotherapy. The patients were divided into effective group（CR+PR） and ineffective group（SD+PD）. We analyzed different chemotherapy effects and clinical pathological parameters（age， sex， location， tumor size， pathological type， clinical stage and differentiation degree） as well as the relationship between the SNPs locus genotype and allele.
ResultsThere was no significant difference between genotype distribution and predictive value of DNMT3b rs6119954, rs1569686， rs4911107， rs4911259， rs8118663 and rs2424913 in 178 patients with advanced colorectal cancer（P>0.05）. After 4 cycles of chemotherapy， there were 4 cases of CR， 45 cases of PR， 88 cases of SD and 41 cases of PD and then the patients were divided into effective group（n=49） and ineffective group（n=129）. The effect of FOLFOX4 chemotherapy was not related to age， sex， location， tumor size and pathological type， but was related to degree of differentiation（P<0.05）. In rs6119954 and rs2424913， the effective rate of chemotherapy was low， and the risk of ineffective chemotherapy was increased with statistical significance difference（P<0.05）. The distribution of the remaining SNPs loci was not related to the efficacy and the risk of invalid efficacy（P>0.05）. ConclusionDNMT3b rs6119954 and rs2424913 were associated with the efficacy of FOLFOX4 in patients with advanced colorectal cancer. The patients carrying rs6119954 A or rs2424913 T allele have a higher risk invalid efficacy of FOLFOX4 regimen，which has a certain value to predict the efficacy of FOLFOX4 regimen for patients with advanced colorectal cancer.

Related Articles | Metrics

Clinical observation of TPF scheme induction with S-1 concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma

JIANG Yingqiang，ZHONG Hui，LI Ming，SONG Gaoping

Chinese Clinical Oncology. 2016, 21 (6): 525.

Abstract ( 456 )

PDF（pc） (895KB) ( 318 )

Save

Objective To evaluate the safety and clinical effects of TPF scheme induction chemotherapy with S-1 concurrent chemotherapy combined with intensitymodulated radiotherapy（IMRT） in the treatment of locally advanced nasopharyngeal carcinoma. MethodsInduction chemotherapy with concurrent chemoradiotherapy combined with IMRT in the treatment of 38 patients with locally advanced nasopharyngeal carcinoma. The induction chemotherapy was used by the TPF scheme: paclitaxel 135 mg/m2， intravenous infusion d1； DDP 80 mg/m2， intravenous infusion，d1； 5fluorouracil 750 mg/（m2•d）， continuous venous pumping，d1d5 （120 hours）. 21 days as a cycle for 2 cycles. The concurrent chemotherapy was used by 40 mg/m2 of S-1， taken orally， twice a day，d1-d14. 2l days as a cycle for 2-3 cycles. The concurrent radiotherapy was PGTVnx（69.96-73.92）Gy/33 f，PGTVnd 69.96 Gy/33 f， PTV1 60.06 Gy/33 f，PTV2 50.96 Gy/28 f，PTVnd 50.96 Gy/28 f，once a day，5 times a week. Results All of 38 patients completed the induction chemotherapy for 2 cycles and concurrent chemoradiotherapy for 2-3 cycles. The immediate effects was evaluated after the treatment. There were 29 cases of CR， 8 PR， 1 SD with 974% of the response rate（RR）. The shortterm effecacy was evaluated in three months after the treatment. There were 33 cases of CR， 5 PR with RR of 100%. The main side effects of induction chemotherapy were nausea， leukocyte and hemoglobin decrease， those of concurrent chemoradiotherapy were oral mucositis， dermatitis in the radiation field and odynophagia. Among them， the grade 3 mucositis （7.9%）， dermatitis in the radiation field （2.6%） and odynophagia （2.6%） were occurred， without grade 4-5 toxicity.
ConclusionTPF scheme inducing chemotherapy with S-1 concurrent chemoradiotherapy combined with IMRT in the treatment of nasopharyngeal carcinoma， has a great shortterm effects and less side effects， which is an effective， tolerable and safe comprehensive treatment scheme.

Related Articles | Metrics

Clinical observation of gemcitabine plus S-1 as a second-line therapy in aged patients with stage ⅢB squamous cell lung cancer

ZHANG Jie， XU Ke， WANG Shaolong

Chinese Clinical Oncology. 2016, 21 (6): 530.

Abstract ( 402 )

PDF（pc） (923KB) ( 331 )

Save

Objective To explore the effect of gemcitabine （GEM） plus S-1 （GS） regime as a second-line therapy in aged patients with stage ⅢB nonoperative squamous cell lung cancer. Methods The clinical data of these eligible patients was collected from November 2009 to September 2014. A total of 105 patients were randomized divided into GS group and GEM group. Response to chemotherapy was assessed by RECIST criteria 1.1 and toxicity was evaluated according to National Cancer Institute Common Toxicity Criteria 4.0. The clinical followup data from chemotherapy were investigated. The factors influencing the prognosis of the patients with Cox risk proportional regression model. Results All 105 patients were evaluable for recent efficacy and safety. The response rate and the disease control rate were 39.62% （21/53） and 49.06% （26/53） in GS group， higher than 19.23% （10/52） and 26.92% （14/52） of GEM group （P<0.05）. The median progressionfree survival and overall survival were 4.3 months and 9.2 months in the GS group， better than 3.8 months and 8.0 months in the GEM group （P<0.05）. Compared with GEM group， the incidences of white blood cell decrease， nausea and vomiting， diarrhea， constipation， abdominal pain， mouth ulcers， skin rash and fatigue were significantly higher in GS group than in GEM group （P<0.05）. TNM stage and development time were the independent factors affecting the overall survival by multiple factor analysis. Conclusion The GS regimen is more benifitial than the GEM monotherapy regimen as the secondline therapy in treating elder patients with squamous cell lung cancer in improving the efficacy and prognosis. The adverse reactions were more serious in GS regimen， which should be used in specific patients with better physical health due to its potential serious adverse events.

Related Articles | Metrics

Efficacy and safety of S-1 combined with compound kushen injection as first-line treatment in older patients with advanced gastric cancer

PIAO Ying， ZHENG Zhendong， TANG Ling， TAN Linshen， LIU Zhaozhe， ZHANG Guojing， XIE Xiaodong

Chinese Clinical Oncology. 2016, 21 (6): 535.

Abstract ( 438 )

PDF（pc） (915KB) ( 311 )

Save

Objective To explore the effecacy and safety of S-1 plus compound kushen injection curative treatment for advanced gastric cancer. Methods Sixty-three elderly patients over the age of 70 with gastric cancer from the general hospital of shenyang military region were enrolled，excluding 4 patients of disease progression and fall off. Fifty-nine patients in total according to random number table method were divided into 28 cases as the control group and 31 cases as combined group. The control group was taken S-1 orally（40 mg/m2）， and combined group was taken S-1 plus compound kushen injection. The effecacy，adverse reactions and survival were observed. Results The response rate（RR）and disease control rate（DCR） of combined group were 549% and 903%， which were similar with 39.3% and 85.7% of the control group（P>0.05）. The main side effects were of grade 1-2 in both groups. The incidence of weakness and hepatic injury in combined group were 83.9% and 74.2%， lower than those in control group（100.0% and 96.4%）, respectively（P<0.05）. The median progression-free survival of combined group was 9.0 months， higher than 7.9 months in control group（P<0.05）. The median overall survival in combined group and control group was 14.6 months and 13.1 months（P>0.05）. ConclusionS-1 combined with compound kushen injection for the treatment of elderly advanced gastric cancer has a longer progression-free survival with slight adverse reactions，worthy of clinical promotion.

Related Articles | Metrics

Clinical study of irinotecan plus cisplatin regimen versus irinotecan alone as secondline chemotherapy for advanced gastric cancer

LI Jiangwang， HUANG Chunzhen， YUAN Jianhua， CHEN Qionghui， LIU Yingping， ZHANG Shubo

Chinese Clinical Oncology. 2016, 21 (6): 540.

Abstract ( 412 )

PDF（pc） (958KB) ( 309 )

Save

Objective To investigate the therapeutic effect， long term survival and side effects on advanced gastric cancer patients treated with irinotecan（CPT-11） plus cisplatin（DDP） regimen and CPT-11 alone as secondline chemotherapy. Methods A total of 168 gastric cancer patients enrolled from June 2012 to January 2014 failed in firstline chemotherapy were randomly allocated to CPT-11+DDP group（CPT-11 250mg/m2 iv， d1； DDP 70 mg/m2 iv， d1， 21 days as a cycle） or CPT-11 group（250 mg/m2 iv，d1，21 days as a cycle） with 68 cases in each group. Short-term efficacy was evaluated after 2 cycles’ therapy， and long-term efficacy， as well as side effects was compared between both groups. Results Efficacy could be evaluated in 168 cases. In CPT-11+DDP group，there were 3 cases in CR， 11 in PR， 44 in SD， and the response rate（RR） and disease control rate（DCR） were 167% and 890%. In CPT-11 group， there were 1 case in CR， 12 in PR， 41 in SD，and RR, DCR were 155% and 643%. The difference of RR and DCR had no significance between both groups（P=0.834， P=0.513）. The median progressionfree survival were 4.6 and 4.1 months in CPT-11+DDP group and CPT-11 group（P=0.522）， and the median overall survival（OS） were 13.8 and 12.5 months， respectively（P=0.185）. The incidences of grade 3-4 anemia， grade 3-4 liver impairment and grade 1-4 kidney impairment were higher in CPT-11+DDP group than in CPT-11 group（P<0.05）. The incidences of grade 1-4 constipation and mucositis were lower in CPT-11/DDP group than in CPT-11group（P<0.05）. Subgroup analysis revealed that the median OS of CPT-11/DDP group was significantly better than that of CPT-11 group（15.6 months vs. 13.6 months， P=0.016）. Conclusion Compared with CPT-11monotherapy，CPT-11/DDP regimen shows no survival benefit as second-line treatment for advanced gastric cancer. However， intestinal type of gastric cancer can benefit from CPT-11/DDP regimen，and side effects are well tolerated，worthy of further observation.

Related Articles | Metrics

Clinical analysis of robot-assisted endometrial cancer staging surgery

DING Xiaoping，HOU Qingxiang，XIN Lingli

Chinese Clinical Oncology. 2016, 21 (6): 545.

Abstract ( 382 )

PDF（pc） (1287KB) ( 411 )

Save

Objective To investigate the clinical efficacy and application value of robot-assisted endometrial cancer staging surgery. Methods We retrospectively analyzed 30 patients underwent robot-assisted endometrial cancer staging surgery from March 2010 to March 2015. Results The mean operation time was （218.2±32.5）min. The mean intraoperative blood loss was （136.8±60.1）ml. The mean number of lymph node was （23.9±4.4）. The mean postoperative bowel recovery time was （1.3±0.6）d. The mean time of antibiotic usage was （5.1±3.7）d， and the mean postoperative hospital stay time was （9.2±5.3）d. Three cases experienced urinary tract infection，1 case experienced pelvic lymph cyst，and 1 case experienced limb thrombosis. Conclusion Robot-assisted endometrial cancer staging surgery is safe and feasible.

Related Articles | Metrics

Short-term efficacy of relieving the tumorous airway obstruction by intratracheal radiotherapy plus external irradiation

LIAO Chen，YANG Jiu，ZHU Nuo，LIU Zhiyuan，HONG Mei

Chinese Clinical Oncology. 2016, 21 (6): 549.

Abstract ( 421 )

PDF（pc） (877KB) ( 275 )

Save

Objective To observe the shortterm efficacy of relieving the airway obstruction in patients with local advanced lung cancer by intratracheal radiotherapy combined with external irradiation. Methods During August 2013 to October 2015， 31 local advanced lung cancer patients with airway obstruction were undergone intratracheal radiotherapy（5 Gy/f×23 f） and simultaneously received external irradiation with DT （intratracheal radiotherapy+external irradiation） of 65 Gy. Clinical efficacy was evaluated by Canadian Medical Research Council （MRC） dyspnea scale and the degree of airway stenosis. Results All patients with airway obstruction revealed better efficacy in dyspnea and airway stenosis classification after treatment（P<0.01）. Among them， the MRC grade was found lower than 2 in 28 cases， and the degree of airway stenosis was found lower than 1 in 24 cases. The main adverse events were slight haemoptysis （2 cases）， tracheal mucosa edema （1 case），≥grade 2 pneumonitis （9 cases） and ≥grade 2 esophagitis （5 cases）. In this study, 28 of 31 patients were followed up for 3 months （1 death case and 2 cases were lost） and no recurrent airway stenosis was observed. Conclusion Intratracheal radiotherapy combined with external irradiation can efficiently treat the tumorous airway obstruction.

Related Articles | Metrics

Ultrasonic diagnosis on superficial schwannoma

XIAO Ying

Chinese Clinical Oncology. 2016, 21 (6): 553.

Abstract ( 421 )

PDF（pc） (1594KB) ( 375 )

Save

Objective To discuss the characteristics of ultrasonography on diagnosis of superficial schwannoma. Methods Retrospective analysis of 36 patients ultrasonically diagnosed as superficial schwannoma from January 2014 to June 2015 was done. Results The mass detective rate was 1000%. Among the 36 patients， 24 were confirmed as schwannoma by pathology， and the coincidence rate of ultrasound and pathology was 667%. The shape of schwannoma was round or oval with clear borders. One case was found multiple foci， and the remaining 23 cases showed single lesion. Among the 24 cases， 18 cases showed low echo，and 6 cases showed cystic solid echo. Typical ultrasonographic performance of rat tail was found in 18 cases. According to Adler classification，there were 4 cases in grade 0， 7 in grade Ⅰ， 10 in grade Ⅱ and 3 in grade Ⅱ. ConclusionUltrasonic diagnosis on superficial schwannoma has high diagnostic value with the advantage of easy operation and noninvasion， and is worthy of clinical application.

Related Articles | Metrics

Research progress of intralesional injection for advanced skin melanoma

TANG Bixia，CUI Chuanliang，GUO Jun

Chinese Clinical Oncology. 2016, 21 (6): 556.

Abstract ( 429 )

PDF（pc） (902KB) ( 342 )

Save

Intralesional injection is an antitumor therapy in which the injected agents shrink the tumor directly and stimulate a systemic immune response to kill noninjected tumors（namely bystander effect）. Talimogene laherparepvec， an intralesional injection agent， was approved by U.S. Food and Drug Administration on October， 2015 for the local treatment of unresectable cutaneous， subcutaneous and nodal lesions in patients with melanoma recurrent after initial surgery， inspiring more attention to this treatment method. In the current review， we summarize a series of intralesional injection agents（including cytokines， plasmid， oncolytic virus， etc.） for melanoma and propose future study in this field.

Related Articles | Metrics

Application progress of bladder hyperthermic perfusion chemotherapy after transurethral resection of bladder tumor

WANG Yu， LI Yugang

Chinese Clinical Oncology. 2016, 21 (6): 560.

Abstract ( 494 )

PDF（pc） (891KB) ( 305 )

Save

Bladder cancer is the most common malignant tumor of urinary system， which has taken the first place in the incidence of urinary reproductive system tumor in our country. The method of bladder hyperthermic perfusion chemotherapy was proved to be a useful and effective method in the prevention of superficial bladder cancer recurrence of patients with superficial bladder cancer after transurethral resection. This article will focus on the clinical applications of bladder hyperthermic perfusion chemotherapy in the bladder cancer.

Related Articles | Metrics

Progress in gastric cancer therapy through targeting VEGF/VEGFR pathway

YU Zijun， HOU Helei， ZHANG Xiaochun

Chinese Clinical Oncology. 2016, 21 (6): 564.

Abstract ( 427 )

PDF（pc） (930KB) ( 472 )

Save

Gastric cancer is one of the most common malignancies in the world. The early diagnosis rate of gastric cancer is low and the efficacy of surgery， radiotherapy and chemotherapy for advanced gastric cancer is limited. Since 1971， Folkman first put forward that the development and metastasis of solid tumors depended on angiogenesis. Targeting tumor angiogenesis has opened a new era in anticancer research. Vascular endothelial growth factor（VEGF） is one of the most potent angiogenic factors which could be secreted by many solid tumors and high VEGF expression is one of the characteristic features of gastric carcinomas. VEGF and its receptor VEGFR played important roles in the occurrence and development of gastric cancer. Therefore， disrupting VEGF/VEGFR signal pathways is considered to be a promising strategy for gastric cancer treatment. This article focuses on the most recent development of the VEGF/VEGFR signal transduction pathways and antiangiogenesis therapy in advanced gastric cancer， especially through targeting VEGF/VEGFR pathway.

Related Articles | Metrics

Progression of long non-coding RNA PVT1 in tumor

WAN Li，MA Tianyun，WANG Zhaoxia

Chinese Clinical Oncology. 2016, 21 (6): 569.

Abstract ( 441 )

PDF（pc） (902KB) ( 332 )

Save

Long non-coding RNA（lncRNA） plays a significant role in tumor occurrence and development. Recent studies have found that lncRNA PVT1 was high expression in a wide variety of tumors（breast cancer， hepatocellular carcinoma， gastric cancer， colon cancer， etc.） and performed various biological functions， such as competing endogenous RNAs（ceRNAs）， maintaining important oncogene protein stability，participating in tumor chemotherapy drug resistance. This paper reviews progression of lncRNA PVT1 expression， biological functions， molecular mechanism in tumor from the latest articles home and abroad.

Related Articles | Metrics

标准刊号：	ISSN 1009-0460
	CN 32-1577/R