Chinese Clinical Oncology

Prospective， multicenter clinical study of rmhTNF-NC injection in the treatment of Chinese malignant pleural effusion or peritoneal effusion patients

QIN Shukui， LIU Xiufeng， MA Jun，ZHU Jun， ZHANG Weijing， LIU Xiaoqing， ZHOU Jianying， GU Kangsheng， LIN Yong， WU Changping， ZHUANG Zhixiang， SHI Qingming， CHENG Xianping， MENG Shuiping， CHEN Qun， ZHAO Heping， BAO Yangyi， YUAN Xia， FANG Cantu， ZENG Bairong， WANG Zhidong， FENG Qingliang， WANG Chuntang， YANG Xigui， CHEN Youshan， WU Yanmin.

Chinese Clinical Oncology. 2016, 21 (7): 577.

Abstract ( 618 )

PDF（pc） (939KB) ( 592 )

Save

Objective To investigate and confirm the clinical efficacy and safety of recombinant mutant human tumor necrosis factorNC （rhTNF-NC，Tianenfu） injection in the treatment of malignant pleural effusion and peritoneal effusion. MethodsIt was a perspective，openlabel，single arm and multi-center study，conducted in 82 cancer centers in China. From April 25 2013 to August 31 2015， a total of 985 patients with middle and large amount of malignant pleural effusion or peritoneal effusion were enrolled into this study. rmhTNFNC was infused intralpeurally at a dose of 300 KU each time at d₁， d₄， d₇， or d₁₀， and 3-4 times was regarded as one course. The efficacy and safety were evaluated according WHO and NCI CTC AE 3.0 criterion respectively. ResultsAmong 985 patients， the efficacy could be evaluated in 916 cases （93.00％） with dropout rate of 7.00％. In 916 patients， the objective response rate （ORR） was 6244％ and disease control rate （DCR） was 97.27％. ORR of 614 malignant pleural effusion cases and 302 malignant peritoneal effusions cases were 70.52％ and 46.03％ respectively（P＜0.05）. Two-classification Logistic regression showed that effusion position， treatment condition （initial treatment vs. retreatment） were independent factors influencing ORR of rmhTNF-NC in the treatment of malignant pleural effusion or peritoneal effusion（P＜0.05）， treatment condition was the independent factor influencing ORR of rmhTNF-NC in the treatment of malignant pleural effusion （P＜0.05）， and gender， PS score before treatment and treatment condition were independent factors influencing ORR of rmhTNF-NC in the treatment of malignant peritoneal effusion（P＜0.05）. The major adverse effects （AE） were fever （14.01％） and chill （10.05％）. Other AE included fatigue（1.02％）， pain（0.81％）， constipation（0.61％）， transaminase lift（0.51％），decreased renal function（0.30％）， shortness of breath（0.20％）， rashes（0.20％）and leucopenia（0.20％）. The vast of those AE was in grade 1 or grade 2， and could be reversible. There was no grade 4 AE and drug related death happened. ConclusionrmhTNF-NC injection is effective and safe in control of malignant pleural effusions or peritoneal effusions， especially better in the early treat and malignant pleural effusions patients， with mild and tolerable adverse effects.

Related Articles | Metrics

Meta-analysis of efficacy and safety of oxycodone hydrochloride sustained-release tablets and immediate-release morphine tablets in the titration therapy on moderate to severe cancer pain

LIU Yong， SONG Zhengbo， LIANG Jun， FAN Bifa， ZHANG Li， LUO Suxia， ZHANG Yiping， WANG Jiejun.

Chinese Clinical Oncology. 2016, 21 (7): 585.

Abstract ( 566 )

PDF（pc） (2914KB) ( 332 )

Save

Objective To evaluate the efficacy and safety of oxycodone hydrochloride sustainedrelease tablets and immediate-release morphine tablets in the titration of patients with moderate or severe cancer pain. Methods China national knowledge infrastructure(CNKI) fulltext database， Chinese science and technology journal fulltext database （VIP） and digital journal full-text database of Wanfang were searched. Oxycodone hydrochloride sustained-release tablets and immediate-release morphine tablets were included into the prospective randomized controlled trial （RCT） of moderate to severe cancer pain titration. Methodological assessment of bias risk of the included studies has been performed. The meta analysis of the included studies has been carried out. Results According to the inclusion criteria， 12 RCTs involving 1131 patients were included and subgroup analysis were performed. Meta-analysis results showed that：（1） As for the 1 h pain relief rate， oxycodone hydrochloride sustained-release tablets was significantly better than immediaterelease morphine tablets（RR=3.16， 95％CI：1.64-6.08， P=0.0006）；（2） As for the 4 h pain relief rate， oxycodone hydrochloride sustained-release tablets was significantly better than immediate-release morphine tablets（RR=2.44， 95％CI：1.49-3.97， P=0.0004）；（3） As for the 24 h pain relief rate， oxycodone hydrochloride sustained-release tablets was significantly better than immediaterelease morphine tablets（RR=1.13， 95％CI：1.04-1.24， P=0.005）；（4） As for the titration cycles， oxycodone hydrochloride sustainedrelease tablets was significantly shorter than immediaterelease morphine tablets （MD=-0.77， 95％CI：-1.14--0.40， P＜0.0001）；（5） As for the time to onset， oxycodone hydrochloride sustained-release tablets was significantly faster than immediaterelease morphine tablets （MD=-29.63， 95％CI：-45.54--13.73， P=0.0003）；（6） In terms of adverse reactions， the incidence of constipation（RR=0.69, 95%CI: 0.52-0.92, P=0.01）， nausea and vomiting（RR=0.57, 95%CI: 0.45-0.73, P＜0.000 01） of oxycodone hydrochloride sustained-release tablets were significantly lower than immediate-release morphine tablets； There was no significant difference in the comparison of other adverse reactions（P＞0.05）. ConclusionOxycodone hydrochloride sustained-release tablets has significantly higher 1 h， 4 h and 24 h pain relief rates than immediate-release morphine tablets so that the titration can be completed faster. And it also has significantly shorter titration cycles and the time to onset. Oxycodone sustained-release tablets performs better than immediate-release morphine tablets in the treatment of moderate and severe cancer pain， and leads to less incidences of constipation， nausea and vomiting. Consequently， it will be a better medication choice for moderate or severe cancer pain titration.

Related Articles | Metrics

Effect of sorafenib on the proliferative inhibition of cervical cancer cells and the influence on the expression of PCNA， Survivin

ZHANG Qiang， CIDAN Wangjiu， SUN Wei， SUN Hongzan， ZHAO Xiangxuan， LU Zaiming， GUO Qiyong

Chinese Clinical Oncology. 2016, 21 (7): 593.

Abstract ( 493 )

PDF（pc） (1677KB) ( 357 )

Save

Objective To explore the influence of sorafenib on the proliferation， apoptosis and expression of PCNA， Survivin of cervical cancer cells. MethodsCervical cancer cells HeLa and SiHa cultured in vitro were divided into blank control group, negative control group（DMSO） and sorafenib experimental group（25， 5， 10， 20 μmol／L）. The light microscope was used to observe the morphological changes. Hoechst 33258 was used to observe nucleus morphological changes in HeLa， SiHa cells treated with sorafenib（20 μmol／L） for 48 h. The effect of sorafenib on the proliferation inhibition of HeLa， SiHa cells was detected by MTS. Immunocytochemical method was used to detect the expression of Survivin with sorafenib（10 μmol／L） acting on HeLa and SiHa cells for 48 h. The influence of sorafenib on the expressions of PCNA, Survivin protein of HeLa, SiHa cells was determined by Western blotting. ResultsAfter HeLa， SiHa cells exposed to sorafenib with different concentration for 48h， the typical apoptotic morphological changes were observed under the light microscope. Hoechst 33258 showed shrink and pyknosis of nucleus， and the fluorescence enhanced obviously. The results of MTS showed that sorafenib significantly inhibited the proliferation of cervical cancer cells in a dosedependent manner（P＜0.05）. Immunocytochemistry showed that in negative control group， the average optical density of Survivin in HeLa， SiHa cells were 0.19±0.05 and 0.17±0.07， higher than 0.13±0.01 and 0.13±0.03 in sorafenib experimental group（P＜0.05）. Western blotting showed that the protein expression of PCNA， Survivin of HeLa and SiHa cells treated by sorafenib was down-regulated compared with the negative control group in a dose-dependent manner. Conclusion Sorafenib induces apoptosis of HeLa and SiHa cells， and inhibits cell proliferation in a dose-dependent manner. The possible mechanism lays in the decrease of PCNA and Survivin in HeLa and SiHa cells.

Related Articles | Metrics

The study on drug reverse effect and reverse mechanism of naringin on multidrug resistant human ovarian cell line SKOV3／DDP

WANG Lei， CAI Liping.

Chinese Clinical Oncology. 2016, 21 (7): 598.

Abstract ( 404 )

PDF（pc） (939KB) ( 381 )

Save

Objective To investigate the effect of naringin on the proliferative inhibition of cisplatin （DDP）resistant ovarian cancer SKOV3／DDP cells in vitro and its reverse effect of drug resistance， as well as the possible mechanisms. MethodsDDP to half maximal inhibitory concentration （IC₅₀） on SKOV3 and SKOV3／DDP cells was determined by MTT method. The proliferatiive inhibition of naringin alone and naringin in combination with DDP on SKOV3／DDP cells was tested by MTT method. Non-cytotoxic naringin was selected， and SKOV3／DDP cells were divided into blank control group， 2.5 μg／ml DDP group， 10 μmol/L naringin group and 10 μmol/L naringin+2.5 μg／ml DDP group. RTPCR and Western blotting was used to detect the MDR1 and MRP2 mRNA levels and protein expressions of Pgp and MRP2. ResultsAfter treated with 1.32 μg／ml DDP for 48 h， the IC₅₀ of SKOV3 cells and SKOV3／DDP cells were 5.48 μg／ml and 14.93 μg／ml， and the resistance index （RI） was 2. 72. Naringin could effectively restrain the proliferation of SKOV3／DDP cells in a time and dose dependent manner. The dose of 10 μmol／L naringin was chosen for the further experiment. The RI was 1.62 and the drug resistance reversal fold was 1.68 times after 10 μmol／L naringin+2.5 μg／ml DDP acted on SKOV3／DDP cells. The mRNA levels of MDR1 and MRP2， as well as the protein expressions of P-gp and MRP2 decreased significantly in 10 μmol／L naringin+2.5 μg／ml DDP group compared with 2.5 μg／ml DDP group （P＜0.05）. ConclusionNaringin can significantly inhibit the proliferation of SKOV3／DDP cells in vitro， and can enhance the sensitivity of SKOV3／DDP cell to DDP. The reversal mechanism of drug resistance may be related to the inhibition of MDR1 and MRP2 mRNA and related proteins.

Related Articles | Metrics

Expression of TAZ and Lats2 in esophageal squamous cell carcinoma and their clinical significance

BAI Fan， JIN Li， HE Xinbin， CHEN Longbang， SONG Haizhu.

Chinese Clinical Oncology. 2016, 21 (7): 603.

Abstract ( 420 )

PDF（pc） (1401KB) ( 284 )

Save

Objective To explore the expression of TAZ and Lats2 in esophageal squamous cell carcinoma（ESCC）， and the correlation of their expression with clinicopathological features and prognosis. MethodsTAZ and Lats2 expression were determined by MaxVision immunohistochemical method in 145 ESCC tissues and 39 adjacent normal tissues， and their correlation with clinicopathological features were analyzed. Overall survival（OS） and progressionfree survival（PFS） were further investigated. Results The high expression rate of TAZ in ESCC tissues and adjacent normal tissues was 58.6％（85／145）and 38.5％（15／39）with significant difference（P＜0.05）. TAZ expression level in tumor tissues was correlated with depth of invasion， lymph node status， tumor differentiation, tumor size and pTNM stages（P＜0.05）. The high expression rate of Lats2 in ESCC tissues and adjacent normal tissues was 45.5％（66／145） and 64.1％（25／39） with significant difference（P＜0.05）. Lats2 expression level in tumor tissues was correlated with depth of invasion， lymph node status and pTNM stages（P＜0.05）. In ESCC tissues， the expression of TAZ and Lats2 showed negative correlation（r=-0.272， P=0.001）. The median OS and PFS of patients with high TAZ expression was 30 months and 20 months， lower than 59 months and 57 months of patients with low TAZ expression（P＜0.001）. The median OS and PFS of patients with high Lats2 expression was 42 months and 33 months， higher than 32 months and 18 months of patients with low Lats2 expression（P=0.035， P=0.019）. ConclusionThe expression of TAZ and Lats2 were bound up with the occurrence and progress of ESCC， and it may account for the evaluation and the treatment of ESCC.

Related Articles | Metrics

Expression of GRP78 and KIAA1324 proteins in gastric cancer and their prognostic value

HU Yongwei， HAN Wei， ZHU Rong， CAO Fang， DING Houzhong

Chinese Clinical Oncology. 2016, 21 (7): 609.

Abstract ( 404 )

PDF（pc） (1020KB) ( 290 )

Save

Objective To investigate the expression of GRP78 and KIAA1324 proteins in gastric cancer and their correlation with clinicopathological parameters and prognosis. MethodsImmunohistochemical technique was used to detect the expression of GRP78 and KIAA1324 proteins in 90 cases of gastric cancer tissues. The relationship between the expression of GRP78 and KIAA1324 proteins and clinicopathological parameters was analyzed. The survival rate was calculated by Kaplan-Meier method. The survival differences were analyzed by Log-rank test. Results The positive rates of GRP78 and KIAA1324 were 78.89％（71/90） and 35.56％（32/90）， respectively. The expression of GRP78 and KIAA1324 was correlated with lymph node metastasis and TNM stage （P＜0.05）. The expression of GRP78 was negatively related to expression of KIAA1324（r=-0.469，P＜0.05）.The median survival time of patients with positive expression of GRP78 was 49.78 months（95％CI：44.09~55.46），which was lower than 62.21 months（95%CI: 53.29~71.14） of patients with negative expression of GRP78，with significant difference（P＜0.05）. The median survival time of patients with positive expression of KIAA1324 was 60.66 months（95％CI：53.63~67.69）， which was higher than 47.85 months（95%CI: 41.46~54.23） of patients with negative expression of KIAA1324， with significant difference（P＜0.05）. Conclusion GRP78 and KIAA1324 play important roles in generation and development of tumor， and they may serve as promising targets for therapy of gastric cancer.

Related Articles | Metrics

Correlation analysis between the expression of B7-H3 and the level of macrophages infiltration in hepatocellular carcinoma tissues

KANG Fubiao，WANG Ling，WANG Yan，PENG Huanyan，SUN Dianxing.

Chinese Clinical Oncology. 2016, 21 (7): 613.

Abstract ( 433 )

PDF（pc） (1510KB) ( 285 )

Save

Objective To investigate the relationship between the expression of B7-H3 and the level of tumor-associated macrophages（TAMs） infiltration in hepatocellular carcinoma（HCC） tissues. MethodsThe expression level of B7-H3 was detected by immunohistochemistry and quantitative Real-time PCR in 116 HCC tissues. Immunohistochemistry also was used to detect CD68 expression. Then the relationship between B7-H3， CD68 expression and clinicopathologic features was analyzed. Results Among the 116 cancer tissues， the high expression rate of B7-H3 was 79.3％（92／116）； and patients with the low， middle， high level of TAMs infiltration were 21， 49 and 46 cases. The expression of B7-H3 was related to TNM stage， vascular invasion and microsatellite lesions formation（P＜0.05）； The level of TAMs infiltration was related to TNM stage， vascular invasion， lymph node metastases and microsatellite lesions formation（P＜0.05）. The mRNA level of B7-H3 was significantly correlated with the level of TAMs infiltration （r=0.473，P＜0.001）. ConclusionThe expression level of B7-H3 is positively correlated with the level of TAMs infiltration in HCC tissues, and they may contribute to the oncogenesis and progression of HCC.

Related Articles | Metrics

Expression of EphB6 receptor tyrosine kinase in ovarian serous carcinoma and its clinical significance

DING Jie， ZHANG Rong， YU Minmin， CHEN Changhao， WANG Xiufang.

Chinese Clinical Oncology. 2016, 21 (7): 617.

Abstract ( 456 )

PDF（pc） (3250KB) ( 297 )

Save

Objective To investigate the expression of receptor tyrosine kinase EphB6 in ovarian serous carcinoma and its relationship with clinicopathological characteristics. MethodsImmunohistochemical staining was subjected to a set of paraffin fixed tissue samples including 55 cases of ovarian serous carcinoma， 24 cases of benign carcinoma， 37 cases of borderline carcinoma and 20 cases of normal fallopian tube. The relationship between the expression of EphB6 in ovarian serous carcinoma and clinicopathological parameters and survival was analyzed. ResultsHigh expression of EphB6 was detected in 100.0％（20／20） of normal fallopian tube samples， 100.0％（24／24） of benign carcinoma， 78.4％（29／37） of borderline tumor and 18.2％（10／55） of ovarian serous carcinoma（P＜0.001）. The expression of EphB6 was significantly associated with differentiation， TNM stage and Ki-67（P＜0.005）. The median overall survival of high-level expression group was 103 months， higher than 69（95％CI：26-105）months of moderate and low-level expression group with significant difference（P=0.046）. Conclusion It shows that EphB6 is a new biomarker for distinguishing high and low-grade ovarian serous carcinoma， and maybe a potential prognostic marker.

Related Articles | Metrics

Clinical value of CEA in patients with lung adenocarcinoma and its relationship with epidermal growth factor receptor mutations

LV Yanling， YUAN Dongmei， SONG Yong， JIN Shuxian.

Chinese Clinical Oncology. 2016, 21 (7): 621.

Abstract ( 419 )

PDF（pc） (929KB) ( 275 )

Save

Objective To determine the expression of carcino embryonie antigen（CEA）in serum and pleural effusion in patients with lung adenocarcinoma and its relationship with epidermal growth factor receptor（EGFR）mutations. MethodsSeventynine serum and pleural effusion samples were collected from 79 lung adenocarcinoma patients with malignant pleural effusion. The concentration of CEA was detected by immunoradiometric assay， and the relationship between the level of CEA and EGFR mutations was analyzed. ResultsA total of 35 cases involved EGFR mutations， and the mutation rate of EGFR was 44.3％（35/79）. For the serum CEA， the area under curve（AUC） was 0.661（95％CI：0.536-0.785）. When the cut-off value was 19.5 ng／ml， the efficacy of sensitivity and specificity were best. For the pleural effusion CEA， when the cut-off value was 55.5 ng／ml， the AUC was 0.757（95％CI：0.653-0.862）. The mutation rate was significantly higher in the patients with high serum（≥19.5 ng／ml）and pleural effusion（≥55.5 ng／ml）levels of CEA than those with low expression levels（P＜0.05）. Moreover， the positive rates of EGFR mutations of the three groups（both≥cut-off， any of them≥cut-off and both ＜cut-off）were 64.3％， 60.0％，16.1％， respectively（P＜0.001）. In a multivariate regression analysis， the level of pleural effusion CEA（HR： 1.002， 95％ CI：1.001-1.004， P=0.003）was confirmed as independent factor of predicting EGFR mutations. Conclusion CEA can probably serve as a marker of predicting EGFR mutations.

Related Articles | Metrics

The relationship between serum CEA， CA125 and the mutation rate of EGFR in NSCLC patients

SUN Wenwen，XU Zhihong，GAO Beili，HU Jia'an

Chinese Clinical Oncology. 2016, 21 (7): 626.

Abstract ( 457 )

PDF（pc） (1017KB) ( 309 )

Save

Objective To explore the significance of the quantity and phenotype of the circulating tumor cells（CTCs） to the disease characteristics of non-small cell lung cancer. Methods Twenty-nine advanced lung adenocarcinomas and adenosquamous carcinoma patients were enrolled in this clinical trial. General information and disease status was collected. The former contained the characteristics of age， gender， whether smoking and family history of cancer, and the latter included the characteristics of pathological type， lump location， TNM stage， T stage， N stage， M stage and the metastases in different organs. CanpatrolTMCTC was applied to count the number of CTCs， and the CTCs were divided into three subtypes including epithelial CTCs， biphenotypic CTCs， mesenchymal CTCs. Meanwhile the patients should be checked by computed tomograhy， bone scanning， brain MRI， abdominal ultrasonography and positron emission computed tomography within one month. Mann-Whitney U test or KruskalWallis H test was conducted to analyze the data， and the statistical significance was performed. ResultsTwentyfive patients were detected with CTCs most of which were biphenotypic CTCs. Among the 25 patients， 19 patients were found with bone metastases which were the most common organ that occurring metastases. The total CTCs and biphenotypic CTCs were performed with statistical significance in initialtorelapse patients（P＜0.05）. The enumeration of epithelial CTCs were performed with statistical significance in age， TNM stage， M stage， N stage， extrapulmonary metastases, bone metastases and vertebra metastasis（P＜0.05）. The mesenchymal CTCs were showed statistical significance in the appearance of mediumlarge pleural effusion（P＜0.05）. Conclusion The biphenotypic CTCs were the most common type in late stage of NSCLC. The epithelial CTCs have positive correlation with the TNM stage of advanced lung cancer， M stage and bone metastases. Bone is the most common organ that CTCs is apt to home.

Related Articles | Metrics

Clinical analysis of postoperative sequential chemoradiotherapy in patients with stage I low-grade endometrial stromal sarcoma

CHEN Jiao， KONG Weimin， ZHANG Tongqing，SONG Dan， JIAO Simeng， LI Xia， LIU Yao， SHANG Ruotian.

Chinese Clinical Oncology. 2016, 21 (7): 633.

Abstract ( 476 )

PDF（pc） (931KB) ( 288 )

Save

Objective To investigate the effect of sequential chemoradiotherapy after surgery on survival of patients with stage I low-grade endometrial stromal sarcoma（LGESS）， and evaluate side effects. MethodsA total of 52 patients were collected from June 1995 to December 2010. Twenty-eight patients received sequential chemoradiotherapy following surgery， and 24 patients received surgery alone as control. Patients in sequential chemoradiotherapy group received 2 cycles of chemotherapy（CYVADIC， VAD or IAP regimen）， and then pelvic external radiation was applied with DT of 40-50 Gy. Two cycles of chemotherapy was followed by radiation. The survival and recurrence were evaluated， as well as side effects. ResultsThe median follow-up was 118 months（20-185 months）with the follow-up rate of 92.3％. In 52 patients， 9 cases developed recurrence， with 7 cases relapsed in control group. The 5，10year recurrencefree survival rates were 96.4％ and 91.4％ in sequential chemoradiotherapy after surgery group， higher than 75.0％ and 70.3％ in control group（P=0.035）；the 5，10year overall survival rates had no statistical difference between the two groups（P＞0.05）. All 28 patients with sequential chemoradiotherapy completed treatment. The chemotherapyrelated toxic effects were mainly gastrointestinal reactions and hematologic toxicities， and the gastrointestinal reactions were all grade 1 or 2. Thirteen patients experienced hematologic toxicities and grade 3 or 4 hematologic toxicities were observed in 5 patients， which could recovered after expectant treatment. The radiation reaction was mainly radiation proctitis and vaginitis of grade 1 or 2. No acute grade 3 or 4 radiation toxicities were observed. There was no treatment-related death. Conclusion LGESS has good prognosis, but it is with a tendency to develop late recurrence， even for stage Ⅰ patients. The main treatment is surgery. Sequential chemoradiotherapy after surgery is suggested to reduce the pelvic recurrence， and the toxic effects can be well tolerated.

Related Articles | Metrics

Effect of breast-conserving surgery with modified radical mastectomy on the quality of life in patients with early-stage breast cancer

YI Ying， JIANG Xuemei， LEI Hai， LUO Xue.

Chinese Clinical Oncology. 2016, 21 (7): 638.

Abstract ( 405 )

PDF（pc） (870KB) ( 318 )

Save

Objective To investigate the effect of breast-conserving surgery with modified radical mastectomy on the quality of life of early-stage breast cancer patients. Methods From January 2013 to January 2015， a retrospective analysis of early-stage breast cancer patients（276 cases） in our hospital， including 138 cases of breastconserving surgery group， 138 cases of modified radical mastectomy group. The patients satisfaction， selfrating depression scale （SDS） and selfrating anxiety scale （SAS） were used to evaluate the impact of the quality of life for breast cancer patients in two groups. Rosenberg selfesteem scale （SES）， family cohesion adaptability scale， quality of life measurement table （FA CT-B） were used to perform the questionnaire analysis. ResultsThe SAS and SDS scores of breastconserving surgery group was lower than those of the modified radical mastectomy group with significant statistical difference （P＜0.05）. The patients satisfaction in the breastconserving surgery group was higher than that in the radical mastectomy group， and the difference was statistically significant （P＜0.05）. The measurement results of SES， FA CT-B in the breastconserving surgery group was improved compared with the modified radical mastectomy group（P＜0.05）. Family cohesion and adaptability in the breastconserving surgery group were better than those in the modified radical mastectomy group， and the difference was statistically significant （P＜0.05）. Conclusion The implementation of breastconserving surgery care can improve the quality of life in patients with early-stage breast cancer， relieve patients' psychological and physical discomfort， and promote the rehabilitation of patients.

Related Articles | Metrics

Efficacy observation of albumin-bound paclitaxel plus gemcitabine for the treatment of advanced pancreatic cancer

SONG Chao， FENG Yi， FAN Yue， CHEN Hong， WANG Dansong， ZHOU Yuhong， LOU Wenhui.

Chinese Clinical Oncology. 2016, 21 (7): 642.

Abstract ( 495 )

PDF（pc） (903KB) ( 303 )

Save

Objective To evaluate the efficacy and safety of albumin-bound paclitaxel plus gemcitabine for the treatment of advanced pancreatic cancer patients in Chinese. MethodsFrom March 2012 to January 2015， 27 patients with advanced pancreatic cancer diagnosed by pathology were assigned to receive albumin-bound paclitaxel plus gemcitabine as first-line therapy. Albumin-bound paclitaxel was administered at a dose of 125 mg／m² plus gemcitabine 1000 mg／m² on day 1 and 8 of a 21-day cycle. Response to chemotherapy was assessed by RECIST criteria 1.1 and toxicity was evaluated according to National Cancer Institute Common Toxicity Criteria 3.0. The clinical follow-up data from chemotherapy were investigated for comparison of median progressionfree survival（PFS） and overall survival（OS） between different clinicopathologic characteristics. ResultsAll patients were available for evaluation. None got complete response， 2 cases had partial response and 19 cases had stable disease. The response rate（RR） was 7.4％ and the disease control rate（DCR） was 77.8％. Of the 27 patients， the median PFS was 5.0（95%CI: 4.0-6.7） months and the median OS was 8.0（95%CI: 7.5-13.8） months. The number of chemotherapy cycles were correlated with PFS and OS in pooled treatment arm analyses. The main adverse reactions were nausea and vomiting（48.1％）， fatigue（55.5％）， fever（7.4％）， rash itching（3.7％） and peripheral nerve abnormalities（11.1％）. The major adverse reactions were mainly bone marrow suppression. Among them， grade 3-4 hematologic toxicity included white blood cell reduction， thrombocytopenia and hemoglobin reduction. Conclusion The combination of albumin-bound paclitaxel and gemcitabine is effective and tolerated in the treatment of advanced pancreatic cancer patients in Chinese.

Related Articles | Metrics

Investigation on popular science of malignant tumor and attitude and behavior about prevention and control among the young officers and soldiers

HUANG Yong， QIN Shukui， YU Qiong， CHEN Yingxia， WANG Ling， GENG Haiyun.

Chinese Clinical Oncology. 2016, 21 (7): 646.

Abstract ( 542 )

PDF（pc） (867KB) ( 291 )

Save

Objective To evaluate the young officers and soldiers' popular science of malignant tumor，realize their attitude and behavior about prevention and control，provide the basis for health education. MethodsBased on the principle of systematic sampling，part of the young officers and soldiers was randomly selected. The selfmade questionnaire was used to investigate the young officers and soldiers popular science of malignant tumor. The questionnaire was conducted by face-to-face interview. Results A total of 555 questionnaires were valid， average score of 25.9±5.6. The average score of the basic cognition of malignant tumor， the causes of malignant tumor， early detection of malignant tumor and attitude and behavior about malignant tumor prevention and anticancer were 6.8±2.4， 4.3±1.6， 6.6±2.2 and 8.2±2.6， out of 56.7％， 43.0％， 55.0％， 58.6％.Married／divorcee scored significantly higher than the unmarried， higher education degree was higher than the lower， women higher than men（P＜0.05）. Conclusion The awareness of the young officers and soldiers popular science knowledge of malignant tumor is low， associated with younger respondents and the lack of professional scientific knowledge. Cognitive deficiencies resulted in the fear of malignant tumors， which is not conducive to the scientific and healthy way of life. More attention should be paid on the particular health education to raise the health care consciousness of soldiers and officers.

Related Articles | Metrics

Research progress of tumor-infiltrating lymphocytes in triplenegative breast cancer

FANG Hehui， YANG Fang， GUAN Xiaoxiang.

Chinese Clinical Oncology. 2016, 21 (7): 650.

Abstract ( 402 )

PDF（pc） (890KB) ( 410 )

Save

Triplenegative breast cancer（TNBC） is a heterogeneous disease. It is often characterized by the lack of specific therapeutic molecular targets and poor prognosis. There are increasing evidences about the relationship between tumorinfiltrating lymphocytes and the prognosis of TNBC. However， the distinction between different types of T lymphocytes is extremely important， because of their different roles in the tumor microenvironment. Moreover， tumor-associated macrophages have been associated with a relatively poor outcome in TNBC. In this article， we review the role of different lymphocyte infiltration in the clinical outcome of TNBC.

Related Articles | Metrics

The predictive value of UGT1A gene polymorphism on irinotecan induced toxicity and effect in Chinese metastatic colorectal carcinoma

LIU Dan， LI Jian， SHEN Lin.

Chinese Clinical Oncology. 2016, 21 (7): 654.

Abstract ( 490 )

PDF（pc） (960KB) ( 472 )

Save

Chemotherapy is dominated treatment measure in metastatic colorectal carcinoma and irinotecan is one of effective chemotherapy drugs. However， the disadvantage of irinotecan is limited effect and varied adverse effects in different patients. So it is of great importance to explore effective bio-markers and screen the patients who potential benefit from irinotecan with good tolerance. The gene polymorphism of UGT1A is closely related to the adverse effects and benefit of irinotecan with controversial analysis results. This review referred the limitation of UGT1A gene polymorphisms prediction to irinotecan. It might be accounted for ethnicity， dose， drugs used in combination or targeted drugs. It is a more effective pattern to predict the benefit and adverse effects by combined gene polymorphism examination of CES， ATP blinding cassette transporter， CYP3A4， SCOL and so on.

Related Articles | Metrics

Progress on TLR4 and tumor cells apoptosis

SUN Shanmei， SONG Lucheng.

Chinese Clinical Oncology. 2016, 21 (7): 661.

Abstract ( 591 )

PDF（pc） (1013KB) ( 574 )

Save

Toll like receptor 4（TLR4）as a pattern recognition receptor， which is a research hotspot of tumor immunology in recent years. It plays an important role in inhibiting the regulation of tumor cells apoptosis. TLR4 is mainly through two signal pathway on the regulation of tumor cells apoptosis： the first way is that TLR4 through MyD88 protein regulates NF-kappa B to promote the proliferation of tumor cells； the other is that TLR4 inhibits tumor cells apoptosis through PI3K/Akt signaling pathway. In this review， we discuss the correlation between TLR4 and tumor cells apoptosis， which may provide new ideas on diagnosis and treatment of tumor cells apoptosis.

Related Articles | Metrics

Progress of accurate radiotherapy in thyroid cancer

WU Changhua， HAN Dali， WANG Liang， CHEN Wanjun.

Chinese Clinical Oncology. 2016, 21 (7): 665.

Abstract ( 451 )

PDF（pc） (900KB) ( 480 )

Save

Thyroid carcinoma is the most common malignant tumor of the endocrine system， which can be divided into four kinds according to the pathological type： papillary thyroid carcinoma， follicular thyroid carcinoma， medullary thyroid carcinoma and undifferentiated thyroid cancer. The first two are known together as differentiated thyroid cancer due to the high level of differentiation. The initial management of differentiated thyroid cancer is surgery， followed by radioactive iodine for gross residual or unresectable disease. For both differentiated thyroid cancer and medullary thyroid cancer， the role of external beam radiotherapy after resection of gross disease when there is a high risk of local regional failure is reviewed. Accurate radiotherapy can reduce the risk of the local recurrence and the radiation injury to normal tissue. In anaplastic thyroid cancer， although most patients present with unresectable disease and radiotherapy is the mainstay of treatment， the benefits of the addition of chemotherapy to radiation therapy will be discussed. External beam radiotherapy not only plays a role as a part of combined treatment of preoperative and postoperative， but also can be used separately to alleviate symptoms， control the growth of the lesion and prolong the overall survival to serve the purpose of palliative treatment.

Related Articles | Metrics

标准刊号：	ISSN 1009-0460
	CN 32-1577/R